[ RadSafe ] " Caffeine and exercise can team up to prevent skin cancer "

[Peter Bossew]

I recommend vodka for that purpose.
Lots of.

(At least this is what I have learnt in Chernobyl. They say this is what 
works best against all imaginable plus yet to be discovered effects of 
ionizing radiation PLUS radiophobia.)


pb




Franta, Jaroslav wrote:
> Wonder if this also works for ionizing radiation ?
>
>
> http://www.physorg.com/news105033035.html
> July 30, 2007
> Caffeine and exercise can team up to prevent skin cancer
>
> Regular exercise and little or no caffeine has become a popular lifestyle
> choice for many Americans. But a new Rutgers study has found that it may not
> be the best formula for preventing sun-induced skin damage that could lead
> to cancer. Low to moderate amounts of caffeine, in fact, along with exercise
> can be good for your health. 
>
> According to the National Cancer Institute, sunlight-induced skin cancer is
> the most prevalent cancer in the United States with more than 1 million new
> cases each year. A research team at Rutgers, The State University of New
> Jersey, showed that a combination of exercise and some caffeine protected
> against the destructive effects of the sun's ultraviolet-B (UVB) radiation,
> known to induce skin cancer. The caffeine and exercise seemingly conspire in
> killing off precancerous cells whose DNA has been damaged by UVB-rays. 
>
> The studies, conducted in the Susan Lehman Cullman Laboratory for Cancer
> Research at Rutgers' Ernest Mario School of Pharmacy, appear in the July 31
> Proceedings of the National Academy of Sciences. 
>
> Groups of hairless mice, whose exposed skin is vulnerable to the sun, were
> the test subjects in experiments in which one set drank caffeinated water
> (the human equivalent of one or two cups of coffee a day); another
> voluntarily exercised on a running wheel; while a third group both drank and
> ran. A fourth group, which served as a control, didn't run and didn't
> caffeinate. All of the mice were exposed to lamps that generated UVB
> radiation that damaged the DNA in their skin cells. 
>
> Some degree of programmed cell death, also known as apoptosis, was observed
> in the DNA-damaged cells of all four groups, but the caffeine drinkers and
> exercisers showed an increase over the UVB-treated control group. Apoptosis
> is a way in which cells with badly damaged DNA commit suicide - UVB-damaged
> cells in this case. 
>
> "If apoptosis takes place in a sun-damaged cell, its progress toward cancer
> will be aborted," said Allan Conney, director of Rutgers' Cullman Laboratory
> and one of the paper's authors. 
>
> To determine the extent of programmed cell death among the four groups of
> UVB-treated mice, the Rutgers team looked at physical changes in the cells.
> The scientists also relied on chemical markers, such as caspase-3 - an
> enzyme that is involved in killing DNA-damaged cells - and p53, a tumor
> suppressor. 
>
> "The differences between the groups in the formation of UVB-induced
> apoptotic cells - those cells derailed from the track leading to skin cancer
> - were quite dramatic," Conney said. 
>
> Compared to the UVB-exposed control animals, the caffeine drinkers showed an
> approximately 95 percent increase in UVB-induced apoptosis, the exercisers
> showed a 120 percent increase, while the mice that were both drinking and
> exercising showed a nearly 400 percent increase. 
>
> "The most dramatic and obvious difference between the groups came from the
> caffeine-drinking runners, a difference that can likely be attributed to
> some kind of synergy," Conney said. The authors suggested several mechanisms
> at the biochemical level that might be responsible for the protective
> effects of caffeine and exercise, but acknowledged that what is happening
> synergistically is still somewhat of a mystery. 
>
> "We need to dig deeper into how the combination of caffeine and exercise is
> exerting its influence at the cellular and molecular levels, identifying the
> underlying mechanisms," Conney said. "With an understanding of these
> mechanisms we can then take this to the next level, going beyond mice in the
> lab to human trials. With the stronger levels of UVB radiation evident today
> and an upward trend in the incidence of skin cancer among Americans, there
> is a premium on finding novel ways to protect our bodies from sun damage." 
>
> Source: Rutgers, the State University of New Jersey
> =============================
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-- 


-----------------------------------------------------
Peter Bossew 

European Commission (EC) 
Joint Research Centre (JRC) 
Institute for Environment and Sustainability (IES) 

TP 441, Via Fermi 1 
21020 Ispra (VA) 
ITALY 
  
Tel. +39 0332 78 9109 
Fax. +39 0332 78 5466 
Email: peter.bossew at jrc.it 

WWW: http://rem.jrc.cec.eu.int 
  
"The views expressed are purely those of the writer and may not in any
circumstances be regarded as stating an official position of the European
Commission."