[ RadSafe ] Bystander Effect" Hints at Dangers of Low-DoseRadiation

Wed Aug 20 13:00:58 CDT 2008

It looks like the heads of the 3 Gy irradiated mice received ~0.036 Gy (3.6 rad).

It is a "Open Access" article, so it is a free download.

<http://www.pnas.org/content/early/recent> Early Edition Articles (date view) - PNAS>

   Medical Sciences:
   Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum
   PNAS published August 18, 2008, doi:10.1073/pnas.0804186105
   http://www.pnas.org/content/early/2008/08/15/0804186105.full.pdf+html

   Shielding was checked by dosimetry and Monte Carlo simulation. The dose
   due to primary photons beneath the shields was 0.26%. Shielded
   tissues, however, receive scattered radiation due to x-ray deflection
   through irradiated tissues. A conservative value of the dose (attenuated
   scattered) of 1.2% of the total dose to shielded tissues was
   estimated. Thus, another cohort of mice was WB exposed to 0.036
   Gy as internal control. Two additional cohorts were sham irradiated,
   or left untreated (CN).

Don't have time right now to actually read the paper.

Best regards,
Cary

---
Cary Renquist
RSO, Eckert & Ziegler Isotope Products
Office: +1 661-309-1033
cary.renquist at ezag.com

-----Original Message-----
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On Behalf Of Glenn R. Marshall
Sent: Wednesday, 20 August, 2008 07:28
To: ROY HERREN; radsafe at radlab.nl
Subject: RE: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-DoseRadiation

I don't deal with x-ray machines at all, so here's a question for the medical HPs out there:  Assuming a newborn baby mouse's head is less than an inch from the part that was x-rayed, what would the dose be to the head due to scatter in the scenario described below?  The article implies the head received zero exposure; obviously that's not true. 

Glenn Marshall, CHP, RRPT

-----Original Message-----
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On Behalf Of ROY HERREN
Sent: Wednesday, August 20, 2008 12:11 AM
To: radsafe at radlab.nl
Subject: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-Dose Radiation

http://sciencenow.sciencemag.org/cgi/content/full/2008/818/3

Bystander Effect" Hints at Dangers of Low-Dose Radiation

By Jocelyn Kaiser
ScienceNOW Daily News
18 August 2008That lead apron you wear during a dental x-ray is supposed to protect the rest of you from radiation. But it may not work very well, according to a new study. When cancer-prone mice were placed in lead containers and irradiated on just the lower half of their bodies, they developed brain tumors. The results suggest that radiation could be riskier than scientists thought. 
The study builds on a surprising effect, first observed 16 years ago. When cells in culture are exposed to ionizing radiation, even those not directly hit sustain damage to chromosomes. Apparently, the irradiated cells pass on a distress signal or emit some chemical that breaks the DNA of neighboring cells (ScienceNOW, 7 September 2005). Although this "bystander effect" has been observed in tissue culture and recently in living animals, no experiments have yet linked it to the main reason for concern: Bystander effects might trigger cancer. Some scientists even suspect the opposite--that the bystander responses could protect against the disease by killing damaged cells. 
Now it seems that the cancer risk is real. Radiation oncologist Anna Saran at the Italian National Agency for New Technologies, Energy and the Environment in Rome and colleagues studied mice with a mutation in a gene called Patched that makes them susceptible to brain tumors early in life. They placed newborn mice in lead shields that protected their heads and upper bodies, then zapped them with high-dose x-rays, or about 12,000 times the dose of a dental or chest x-ray. The scientists found that the cerebellums of these animals had higher than normal amounts of DNA damage and apoptosis, or programmed cell death. By 40 weeks of age, 39% of the shielded mice had developed brain tumors. That's a lot considering that the rate was 62% in Patched mice that were irradiated all over, including their heads. Patched mice that weren't irradiated did not develop brain cancer. 
When the team injected the shielded mice with a chemical that blocks cell-to-cell communication before irradiating them, they detected no DNA breaks and the amount of apoptosis decreased more than threefold. Even though the irradiated tissues are far away from the brain, they are connected by neurons that could be passing on bystander signals, Saran says. The results appear online this week in the Proceedings of the National Academy of Sciences. 
"This is a milestone paper," says Columbia University radiation physicist David Brenner. He suggests that current estimates of cancer risk from low doses of radiation--say, from naturally occurring radon and diagnostic tests--may underestimate the danger by failing to take into account bystander effects. To learn more, however, the mouse work should be repeated with lower doses of radiation, Saran says.

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