WG: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-DoseRadiation

Wed Aug 20 13:39:27 CDT 2008

addendum:

Among all experimental groups the 34 animals experienced the lowest incidence of medulloblastoma which received a homogeneous whole body exposure of the stray dose to the cerebellum, i.e., of 0.036 Gy. Here within the reported observation time the incidence was lower (i.e. zero) than in the unirradiated and sham irradiated controls. 

Hormesis?

Regards, Rainer

Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970

________________________________

Von: Facius, Rainer
Gesendet: Mi 20.08.2008 20:13
An: Glenn R. Marshall; ROY HERREN; radsafe at radlab.nl
Betreff: AW: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-DoseRadiation

The paper states a remaining dose (finite attenuation and scattered photons) of 1.2% of the unshielded whole body dose of 3 Gy, i.e. 0.036 Gy to the cerebrellum.

Rainer

I remember experiments in the 1960s when one hind leg of rats was irradiated and the contralateral shielded hind leg responded with erythema. At that time it was called an "abscopal" rather than a bystander effect. 

Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970

________________________________

Von: radsafe-bounces at radlab.nl im Auftrag von Glenn R. Marshall
Gesendet: Mi 20.08.2008 16:28
An: ROY HERREN; radsafe at radlab.nl
Betreff: RE: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-DoseRadiation

I don't deal with x-ray machines at all, so here's a question for the medical HPs out there:  Assuming a newborn baby mouse's head is less than an inch from the part that was x-rayed, what would the dose be to the head due to scatter in the scenario described below?  The article implies the head received zero exposure; obviously that's not true.

Glenn Marshall, CHP, RRPT

-----Original Message-----
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On Behalf Of ROY HERREN
Sent: Wednesday, August 20, 2008 12:11 AM
To: radsafe at radlab.nl
Subject: [ RadSafe ] Bystander Effect" Hints at Dangers of Low-Dose Radiation

http://sciencenow.sciencemag.org/cgi/content/full/2008/818/3

Bystander Effect" Hints at Dangers of Low-Dose Radiation

By Jocelyn Kaiser
ScienceNOW Daily News
18 August 2008That lead apron you wear during a dental x-ray is supposed to protect the rest of you from radiation. But it may not work very well, according to a new study. When cancer-prone mice were placed in lead containers and irradiated on just the lower half of their bodies, they developed brain tumors. The results suggest that radiation could be riskier than scientists thought.
The study builds on a surprising effect, first observed 16 years ago. When cells in culture are exposed to ionizing radiation, even those not directly hit sustain damage to chromosomes. Apparently, the irradiated cells pass on a distress signal or emit some chemical that breaks the DNA of neighboring cells (ScienceNOW, 7 September 2005). Although this "bystander effect" has been observed in tissue culture and recently in living animals, no experiments have yet linked it to the main reason for concern: Bystander effects might trigger cancer. Some scientists even suspect the opposite--that the bystander responses could protect against the disease by killing damaged cells.
Now it seems that the cancer risk is real. Radiation oncologist Anna Saran at the Italian National Agency for New Technologies, Energy and the Environment in Rome and colleagues studied mice with a mutation in a gene called Patched that makes them susceptible to brain tumors early in life. They placed newborn mice in lead shields that protected their heads and upper bodies, then zapped them with high-dose x-rays, or about 12,000 times the dose of a dental or chest x-ray. The scientists found that the cerebellums of these animals had higher than normal amounts of DNA damage and apoptosis, or programmed cell death. By 40 weeks of age, 39% of the shielded mice had developed brain tumors. That's a lot considering that the rate was 62% in Patched mice that were irradiated all over, including their heads. Patched mice that weren't irradiated did not develop brain cancer.
When the team injected the shielded mice with a chemical that blocks cell-to-cell communication before irradiating them, they detected no DNA breaks and the amount of apoptosis decreased more than threefold. Even though the irradiated tissues are far away from the brain, they are connected by neurons that could be passing on bystander signals, Saran says. The results appear online this week in the Proceedings of the National Academy of Sciences.
"This is a milestone paper," says Columbia University radiation physicist David Brenner. He suggests that current estimates of cancer risk from low doses of radiation--say, from naturally occurring radon and diagnostic tests--may underestimate the danger by failing to take into account bystander effects. To learn more, however, the mouse work should be repeated with lower doses of radiation, Saran says.

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