AW: [ RadSafe ] Benefit from ADJACENT Low-Dose Radiation: "Bystandereffect"?
Rainer.Facius at dlr.de
Rainer.Facius at dlr.de
Fri Aug 22 07:36:31 CDT 2008
it would help your case as well as my curiosity if you were able to provide a reference to the article and/or Jerry's book which would allow me to check it by myself. :-)
Kind regards, Rainer
PS: what about the article, Bobby Scott was referring to in another thread?
Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Voice: +49 2203 601 3147 or 3150
FAX: +49 2203 61970
Von: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] Im Auftrag von HOWARD.LONG at comcast.net
Gesendet: Freitag, 22. August 2008 01:28
An: Facius, Rainer; Grant.NIXON at mdsinc.com; royherren2005 at yahoo.com; radsafe at radlab.nl
Cc: BScott at lrri.org
Betreff: [ RadSafe ] Benefit from ADJACENT Low-Dose Radiation: "Bystandereffect"?
What is the proper term to describe the disappearance of a nasal cancer following torso irradiation with 75 rem?
Examples of such beneficial stimulation of body defences (perhaps in the spleen lymphocytes) are in a book shown me by Cuttler on the way to Palo Verde.
------------- Original message --------------
From: <Rainer.Facius at dlr.de>
> the mechanisms responsible for - the nowadays somewhat
> indiscriminately so called - bystander effects are manifold. They
> comprise both genuine short-range cell to cell communication via
> specific communication channels as well as less specific wide range
> signal transfer via universal 'second messengers', e.g., of the humoral system.
> Personally I reserve the more recent term bystander effect to those
> instances where cells which have received (very) low radiation doses
> signal their resulting response to cells of the same organ or tissue
> which have not received any radiation at all. The - usually few -
> cells 'hit' do transmit their signals via cell and tissue specific
> communication channels whose ordinary function
> (conceivably) is to ensure tissue homeostasis/control.
> For such instances as described by Mancuso et al. (2008) where the
> signals arise from cells rather heavily(!) exposed and where they
> affect cells in distant organs, I prefer the term abscopal effects -
> effects which have been described since decades before the genuine
> bystander effect. Although much of the communication system involved
> is yet to be elucidated the general endocrine system almost certainly is a mayor player.
> Contrary to the quoted statement by Brenner, these results have no
> import whatsoever on radiation protection at low doses. See also the
> corresponding remark from K S Parthasarathy, Mi 20.08.2008 11:56
> Regards, Rainer
> Dr. Rainer Facius
> German Aerospace Center
> Institute of Aerospace Medicine
> Linder Hoehe
> 51147 Koeln
> Voice: +49 2203 601 3147 or 3150
> FAX: +49 2203 61970
> Von: radsafe-bounces at radlab.nl im Auftrag von NIXON, Grant
> Gesendet: Mi 20.08.2008 22:09
> An: HOWARD.LONG at comcast.net; ROY HERREN; radsafe at radlab.nl
> Betreff: RE: [ RadSafe ] Danger of ADJACENT HIGH-Dose Radiation
> To add to Howard's comment:
> Perhaps the mechanism for the DNA damage to adjoining tissue (the
> so-called "bystander effect") is nothing more than a propagated
> free-radical reaction having nothing to do with cell-to-cell
> communication. The high doses would liberate such large numbers of
> free-radicals that the affected perimeter of affected tissues would
> increase on physical grounds alone (diffusion theory coupled with
> target theory). The "chemical that blocks cell-to-cell communication"
> may simply be a free-radical scavenger.
> Grant I. Nixon, Ph.D., P.Phys.
> Science Specialist (Dosimetry/Physics/Engineering) BEST Theratronics
> 413 March Road
> Ottawa, ON K2K 0E9
> tel. (613) 591-2100 x2869
> fax. (613) 591-2250
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