AW: [ RadSafe ] Benefit from ADJACENT Low-Dose Radiation: "Bystandereffect"?

[Rainer.Facius at dlr.de]

Dear Howard,

it would help your case as well as my curiosity if you were able to provide a reference to the article and/or Jerry's book which would allow me to check it by myself. :-)  

Kind regards, Rainer

PS: what about the article, Bobby Scott was referring to in another thread? 

Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970

-----Ursprüngliche Nachricht-----
Von: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] Im Auftrag von HOWARD.LONG at comcast.net
Gesendet: Freitag, 22. August 2008 01:28
An: Facius, Rainer; Grant.NIXON at mdsinc.com; royherren2005 at yahoo.com; radsafe at radlab.nl
Cc: BScott at lrri.org
Betreff: [ RadSafe ] Benefit from ADJACENT Low-Dose Radiation: "Bystandereffect"? 

What is the proper term to describe the disappearance of a nasal cancer following torso irradiation with 75 rem? 

Examples of such beneficial stimulation of body defences (perhaps in the spleen lymphocytes) are in a book shown me by Cuttler on the way to Palo Verde.

Howard Long

------------- Original message --------------
From: <Rainer.Facius at dlr.de> 

> Grant,
> 
> the mechanisms responsible for - the nowadays somewhat 
> indiscriminately so called - bystander effects are manifold. They 
> comprise both genuine short-range cell to cell communication via 
> specific communication channels as well as less specific wide range 
> signal transfer via universal 'second messengers', e.g., of the humoral system.
> 
> Personally I reserve the more recent term bystander effect to those 
> instances where cells which have received (very) low radiation doses 
> signal their resulting response to cells of the same organ or tissue 
> which have not received any radiation at all. The - usually few - 
> cells 'hit' do transmit their signals via cell and tissue specific 
> communication channels whose ordinary function
> (conceivably) is to ensure tissue homeostasis/control. 
> 
> For such instances as described by Mancuso et al. (2008) where the 
> signals arise from cells rather heavily(!) exposed and where they 
> affect cells in distant organs, I prefer the term abscopal effects - 
> effects which have been described since decades before the genuine 
> bystander effect. Although much of the communication system involved 
> is yet to be elucidated the general endocrine system almost certainly is a mayor player.
> 
> Contrary to the quoted statement by Brenner, these results have no 
> import whatsoever on radiation protection at low doses. See also the 
> corresponding remark from K S Parthasarathy, Mi 20.08.2008 11:56
> 
> Regards, Rainer
> 
> 
> 
> Dr. Rainer Facius
> German Aerospace Center
> Institute of Aerospace Medicine
> Linder Hoehe
> 51147 Koeln
> GERMANY
> Voice: +49 2203 601 3147 or 3150
> FAX: +49 2203 61970
> 
> 
> ________________________________
> 
> Von: radsafe-bounces at radlab.nl im Auftrag von NIXON, Grant
> Gesendet: Mi 20.08.2008 22:09
> An: HOWARD.LONG at comcast.net; ROY HERREN; radsafe at radlab.nl
> Betreff: RE: [ RadSafe ] Danger of ADJACENT HIGH-Dose Radiation
> 
> 
> 
> To add to Howard's comment: 
> 
> Perhaps the mechanism for the DNA damage to adjoining tissue (the 
> so-called "bystander effect") is nothing more than a propagated 
> free-radical reaction having nothing to do with cell-to-cell 
> communication. The high doses would liberate such large numbers of 
> free-radicals that the affected perimeter of affected tissues would 
> increase on physical grounds alone (diffusion theory coupled with 
> target theory). The "chemical that blocks cell-to-cell communication" 
> may simply be a free-radical scavenger.
> 
> Grant I. Nixon, Ph.D., P.Phys. 
> Science Specialist (Dosimetry/Physics/Engineering) BEST Theratronics
> 413 March Road
> Ottawa, ON K2K 0E9
> Canada
> tel. (613) 591-2100 x2869
> fax. (613) 591-2250
> 
_______________________________________________
You are currently subscribed to the RadSafe mailing list

Before posting a message to RadSafe be sure to have read and understood the RadSafe rules. These can be found at: http://radlab.nl/radsafe/radsaferules.html

For information on how to subscribe or unsubscribe and other settings visit: http://radlab.nl/radsafe/