[ RadSafe ] ERR query: the exact form of LNT

garyi at trinityphysics.com garyi at trinityphysics.com
Mon Jan 14 22:18:50 CST 2008


Hi Dan,

If it is true that:
> The probability of n = zero tumors is 
> P(n=0 | k, D) = EXP(-kD). 
> 
> The probability of 1 or more tumors (that is, the rest of the universe
> of possible outcomes) is P(n>0 | k, D) = 1 - P(n=0 | k, D) = [1 -
> EXP(-kD)]. Under the linear, non-threshold (LNT) dose-response model,
> [1 - EXP(-kD)] is the exact form of ERR, not simply kD.

then how does the model handle a case where, in absolute risk, R(0) = 0.1 and R(D) = .3 ?
Wouldn't that be ERR = 2.0?  But  1 - EXP(-kD) never > 1.0, so you must mean absolute risk 
or some variant. 

-Gary



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