[ RadSafe ] Uranium and genotoxicity

[Otto G. Raabe]

At 02:31 PM 6/7/2008, you wrote:
>Dear Dr. Raabe: Leach and his associates did not 
>measure genotoxicity, even though karyotyping 
>was readily available to them.  They also did 
>not measure reproductive toxicity. Why did Leach 
>and his associates ignore the 1949 work of 
>Maynard and Hodge? Maynard, EA.; Hodge, HC.. 
>Your statements are quite presumptuous. How do you know that they are true?

>  Studies of the toxicity of various uranium 
> compounds when fed to experimental animals. In: 
> Voegtlin C, Hodge HC. , editors. Pharmacology 
> and Toxicology of Uranium Compounds. New York: 
> McGraw-Hill Book Company, Inc.; 1949. pp. 
> 309­3376. There are reported biological effects 
> in animal studies utilizing really immense 
> doses of the most toxic uranyl ion (UO2--) 
> chemical form of uranium in the U(VI) oxidation 
> state>. Uranium metal and uranium oxide are relatively inert.

See ACUTE CHEMICAL TOXICITY OF URANIUM.
Health Physics. 94(2):170-179, February 2008.
Kathren, Ronald L. *; Burklin, Richard K. +



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Prof. Otto G. Raabe, Ph.D., CHP
Center for Health & the Environment
University of California
One Shields Avenue
Davis, CA 95616
E-Mail: ograabe at ucdavis.edu
Phone: (530) 752-7754   FAX: (530) 758-6140
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