[ RadSafe ] Hormesis in PNAS Article: Oncogenic bystander radiationeffects . .

[HOWARD.LONG at comcast.net]

Myron and radsafers,
Note in Graph 2 D ,  hormesis.
"Mice WBexposed to scatter (0.036Gy)" (34) - did NOT (none) have the expected medulloblastoma, (survival 80% in unexposed controls, 50% in the shielded head "bystander effect" group and 20% in the totally exposed group receiving "12,000 chest x-ray" dose.

Indeed,  heat, sun or ionizing radiation will affect unexposed parts of amimals for good or bad, by many mechanisms, including stimulation of body defenses (like allergy shots) and depend on dose.
This is hormesis. No medulloblastomas in 34 mice receiving 0.036Gy (3.6 rem) when 20% of those with NO radiation died of it by 31 weeks! Kudos to the radsafer who called it to my attention (my recent server change inhibits my naming that contributor)

Howard Long
-------------- Forwarded Message: -------------- 
From: "Cary Renquist" <cary.renquist at ezag.com> 
To: <HOWARD.LONG at comcast.net>, "radsafe" <radsafe at radlab.nl> 
Subject: RE: Fw: Re: [ RadSafe ] PNAS Article: Oncogenic bystander radiationeffects in Patched . . . 
Date: Thu, 4 Sep 2008 18:22:30 +0000 


Just click the link below for a pdf copy of the article. 

>From an earlier post... 

It is a "Open Access" article, so it is a free download. 

Medical Sciences: 
Oncogenic bystander radiation effects in Patched heterozygous mouse 
cerebellum 
PNAS published August 18, 2008, doi:10.1073/pnas.0804186105 
http://www.pnas.org/content/early/2008/08/15/0804186105.full.pdf+html 

Best regards, 
Cary 

-----Original Message----- 
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On 
Behalf Of HOWARD.LONG at comcast.net 
Sent: Thursday, 04 September, 2008 10:30 
To: crispy_bird at yahoo.com; radsafe 
Subject: Re: Fw: Re: [ RadSafe ] PNAS Article: Oncogenic bystander 
radiationeffects in Patched . . . 

John, 
Were you insincere in your offer below to radsafe, to send the article 
you comment upon? 
Can you think of a better way to know that we are discussing exactly the 
same thing? 

Please fax it to 925-846-4524! 

Howard long 

-------------- Original message -------------- 
From: John Jacobus 

> As I mentioned below, I find your question ironic. 
> 
> +++++++++++++++++++ 
> It is also a good rule not to put overmuch confidence in the 
observational 
> results that are put forward until they are confirmed by theory. 
> Arthur Eddington 
> 
> 
> -- John 
> John Jacobus, MS 
> Certified Health Physicist 
> e-mail: crispy_bird at yahoo.com 
> 
> --- On Wed, 9/3/08, HOWARD.LONG at comcast.net wrote: 
> 
> From: HOWARD.LONG at comcast.net 
> Subject: Re: [ RadSafe ] PNAS Article: Oncogenic bystander radiation 
effects in 
> Patched . . . 
> To: crispy_bird at yahoo.com 
> Date: Wednesday, September 3, 2008, 12:32 PM 
> 
> 
> 
> John, 
> I will confirm that we are talking about the same thing when I receive 
your 
> offered fax of the article at 
> 925-846-4524. 
> 
> Thank you, Howard long 
> 
> -------------- Original message -------------- 
> From: John Jacobus 
> 
> 
> 
> 
> You do not know what the discussion is about? I hope you get the 
irony. 
> 
> +++++++++++++++++++ 
> It is also a good rule not to put overmuch confidence in the 
observational 
> results that are put forward until they are confirmed by theory. 
> Arthur Eddington 
> 
> 
> -- John 
> John Jacobus, MS 
> Certified Health Physicist 
> e-mail: crispy_bird at yahoo.com 
> 
> --- On Tue, 9/2/08, HOWARD.LONG at comcast.net wrote: 
> 
> From: HOWARD.LONG at comcast.net 
> Subject: Re: [ RadSafe ] PNAS Article: Oncogenic bystander radiation 
effects in 
> Patched . . . 
> To: crispy_bird at yahoo.com 
> Date: Tuesday, September 2, 2008, 12:08 PM 
> 
> 
> 
> John, to be sure I am reading what you are, please fax it to 
925-846-4524. 
> 
> Thanks, 
> Howard long 
> 
> -------------- Original message -------------- 
> From: John Jacobus 
> 
> > If anyone is interested in a copy of this article please contace me 
directly. 
> > 
> > Mancuso M, et al.,"Oncogenic bystander radiation effects in Patched 
> heterozygous 
> > mouse cerebellum," PNAS, August 26, 2008, Vol. 105, No. 34, Pages 
12445-12450 
> > 
> > I think that is really a first rate experiment demonstration the 
bystander 
> > effect in vivo. 
> > 
> > As a side note, scatter radiation is NOT associated with the 
response 
> observed. 
> > Once again, Dr. Long, it is important to READ the literature, unless 
jumping 
> to 
> > conclusions is the only exercise you get. 
> > 
> > 
> > +++++++++++++++++++ 
> > It is also a good rule not to put overmuch confidence in the 
observational 
> > results that are put forward until they are confirmed by theory. 
> > Arthur Eddington 
> > 
> > -- John 
> > John Jacobus, MS 
> > Certified Health Physicist 
> > e-mail: crispy_bird at yahoo.com 
> > 
> >