[ RadSafe ] Radon and Never Smokers vs Passive Smokers

[Steven Dapra]

Aug. 2

         The Lagarde et al. study is briefly alluded to in a paper by 
Elvira V. Brauner, and published in Environmental Research.

         The link is:

http://www.radonleaders.org/sites/default/files/Environmental_Research.pdf

         Brauner et al. say:

". . . one previous study reports an insignificantly higher relative 
risk for lung cancer in association with residential radon for those 
exposed to ETS (Lagarde et al., 2001)."

         This quote is found on page 6, col. 1, just above the Conclusions.

         Hence, for what it's worth, the Brauner et al. study says 
the Lagarde study's findings are insignificant.

         Wikipedia's summary of Lagarde says:

"the group that had been exposed to passive smoking at home appeared 
to bear the entire risk increase, while those who were not exposed to 
passive smoking did not show any increased risk with increasing radon level."

         This matches the Lagarde abstract, which says:

"The data suggested that among never-smokers residential radon 
exposure may be more harmful for those exposed to environmental tobacco smoke."

Steven Dapra


REFERENCES

Brauner, E.V.,etal., Residential radon and lung cancer incidence in a 
Danish cohort. Environ. Res. 
(2012),  http://dx.doi.org/10.1016/j.envres.2012.05.012

Lagarde et al., Residential radon and lung cancer among never-smokers 
in Sweden. Epidemiology, 2001; July 12(4):396-404.

-----  END -----

Note:

         I have dressed up John Mallon's posting (below) a little 
with paragraphs and quote marks.  I have not altered the text in any way.



At 11:13 AM 8/2/2012, you wrote:
>This item from another list may be of interest to Radsafe. Jim Otton 
>From: International Web Resource for Radon Professionals 
>[mailto:RADONPROFESSIONALS at LIST.UIOWA.EDU] On Behalf Of John Sent: 
>Thursday, August 02, 2012 9:48 AM To: 
>RADONPROFESSIONALS at LIST.UIOWA.EDU Subject: [RNPROF] Never Smokers vs 
>Passive Smokers


>Wikipedia states: "Radon and passive smoking.  An important question 
>is if also passive smoking can cause a similar synergy effect with 
>residential radon. This has been insufficiently studied. The basic 
>data for the European pooling study makes it impossible to exclude 
>that such synergy effect is an explanation for the (very limited) 
>increase in the risk from radon that was stated for non-smokers.


>"A study[111] from 2001, which included 436 cases (never smokers who 
>had lung cancer), and a control group (1649 never smokers) showed 
>that exposure to radon increased the risk of lung cancer in never 
>smokers. But the group that had been exposed to passive smoking at 
>home appeared to bear the entire risk increase, while those who were 
>not exposed to passive smoking did not show any increased risk with 
>increasing radon level.


>"This result needs confirmation by additional studies. Despite the 
>startling results from 2001, new studies seem not to have been implemented."


>The abstract for this study is: Residential radon and lung cancer 
>among never-smokers in Sweden. Lagarde F, Axelsson G, Damber L, 
>Mellander H, Nyberg F, Pershagen G. Source Institute of 
>Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.


>Abstract "In this study, we attempted to reduce existing uncertainty 
>about the relative risk of lung cancer from residential radon 
>exposure among never-smokers. Comprehensive measurements of domestic 
>radon were performed for 258 never-smoking lung cancer cases and 487 
>never-smoking controls from five Swedish case-control studies. With 
>additional never-smokers from a previous case-control study of lung 
>cancer and residential radon exposure in Sweden, a total of 436 
>never-smoking lung cancer cases diagnosed in Sweden between 1980 and 
>1995 and 1,649 never-smoking controls were included. The relative 
>risks (with 95% confidence intervals in parentheses) of lung cancer 
>in relation to categories of time-weighted average domestic radon 
>concentration during three decades, delimited by cutpoints at 50, 
>80, and 140 Bq m(-3), were 1.08 (0.8--1.5), 1.18 (0.9--1.6), and 
>1.44 (1.0--2.1), respectively, with average radon concentrations 
>below 50 Bq m(-3) used as reference category and with adjustment for 
>other risk factors. The data suggested that among never-smokers 
>residential radon exposure may be more harmful for those exposed to 
>environmental tobacco smoke. Overall, an excess relative risk of 10% 
>per 100 Bq m(-3) average radon concentration was estimated, which is 
>similar to the summary effect estimate for all subjects in the main 
>residential radon studies to date."


>If I've read correctly, Wiki says if you never smoke and are not 
>around second hand smoke, don't worry about Radon!  I've not found 
>the full study.  What do you think?  Many people do their research 
>by reading Wiki. My initial reaction is that the conclusion 
>suggested by Wiki is premature  & misleading.


>John Mallon
>Radon Professionals

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