Re: LNT, SNT, or whatever

["Thomas J Savin " <tjsav@lycos.com>]

Hi Bjorn,

I just read your e-mail and a question came to mind.  Are not these tests in vitro ones?  I do know of in vivo hepatocyte removal and examining the tissue after and looking  affects upon the regenerating liver, but this is putting a strain on the renerating tissue (in vivo).  You can get the same results when testing the effect of benzene, and the like - not using radioactive insult.  

I think that some of these tests are misleading and that the whole organism is involved in to combat insult - of course, up to a certain level. 

                      Enjoy,
                            Tom
---
Tom Savin

On Fri, 23 Feb 2001 09:44:55  
 Bjorn Cedervall wrote:
>>Linear is nice and simple as a theory - easy top work with.  It is also
>easy to test.  And - the test failed!
>---
>No threshold has to my knowledge been seen on the level of point mutations, 
>chromosomal aberrations etc. The micronucleus assay gives a straight line 
>down to a level of about 2 mGy per cell generation. The resolution limit is 
>of course determined by statistics (it could probably be pressed down to 
>about 1 mGy/generation with "reasonable" costs). Specific chromosomal 
>aberrations are known to be associated with certain tumors. Knocked out Rb 
>functions (due to point mutations, non-disjunction, deletions etc) result in 
>tumors. There is more along this line.
>
>My personal ideas only (shared by some others however),
>
>Bjorn Cedervall   bcradsafers@hotmail.com
>
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