Re: radiation is good

["Arnold Dion" <asdion@CYBERENET.NET>]

John et al.,



The use of radiolabeled antibodies for tumor detection and treatment dates

back to the 1940's. More recently, humanized, as well as single-chain

antibodies have been shown to be quite effective. The major stumbling block,

as noted by others, remains, i.e.,  penetration of solid tumors, which

account for approximately 85% of human cancers.



Arnold S. Dion, Ph.D.



----- Original Message -----

From: Jacobus, John (OD/ORS) <jacobusj@ors.od.nih.gov>

To: Marco Caceci <mcaceci@radal.com>; Radsafe (E-mail)

<radsafe@list.vanderbilt.edu>

Sent: Tuesday, November 27, 2001 12:05 PM

Subject: RE: radiation is good





> Marco,

> I think that the idea of using radiolabeled antibodies was first

considered

> in the early 1980's.  It is nice to know that they are finally getting

good

> results.  You may also want to see

> http://www.sciam.com/2001/1001issue/1001ezzell.html

>

> -- John

> John Jacobus, MS

> Certified Health Physicist

> 3050 Traymore Lane

> Bowie, MD  20715-2024

>

> E-mail:  jenday1@email.msn.com (H)

>

> -----Original Message-----

> From: Marco Caceci [mailto:mcaceci@radal.com]

> Sent: Tuesday, November 27, 2001 8:52 AM

> To: Radsafe (E-mail)

> Subject: radiation is good

>

> Radionuclides linked to antibodies are finding use as therapeutic agents.

> . . .

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