RE: Chronic Low-Level Radiation Exposure Causes Chromosomal Aberr ations

["Bjorn Cedervall" <bcradsafers@HOTMAIL.COM>]

>The thing that caught my attention most was the size, or lack of, in the 

>sample. Eight people w/ eight controls?

---

They probably counted many thousands of cells. Here is the abstract from 

Medline:



"Evaluation of chromosomal aberrations, micronuclei, and sister chromatid 

exchanges in hospital workers chronically exposed to ionizing radiation.



Cardoso RS, Takahashi-Hyodo S, Peitl P Jr, Ghilardi-Neto T, Sakamoto-Hojo 

ET.



Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, 

Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil.



Cytogenetic analysis was performed in peripheral blood lymphocytes from 

hospital workers chronically exposed to ionizing radiation in comparison to 

matched non-exposed individuals. The accumulated absorbed doses calculated 

for the radiation workers ranged from 9.5 to 209.4 mSv. The endpoints used 

were chromosomal aberrations (CA), micronuclei (MN), and sister chromatid 

exchanges (SCE). The frequencies of CA/100 cells observed for the exposed 

group were significantly (P=0.018) higher than in the control group: 3.2 and 

2.6, respectively. Similarly, the mean numbers of SCE per cell were 

statistically higher (P=0.025) in the exposed group (6.2) in comparison with 

the control group (5.8). In the case of micronuclei analysis, no significant 

(P=0,06) difference between both groups was found, but these data should be 

cautiously interpreted since an increase in the frequencies of MN was found 

for radiation workers (3.0 MN/100 cells), compared to the control group (2.6 

MN/100 cells) and this increase occur in parallel to CA and SCE frequencies. 

The difference between the results could be explained by the nature of CA 

and MN generation. The increased frequencies of CA and SCE in radiation 

workers indicate the cumulative effect of low-level chronic exposure to 

ionizing radiation, and the relevance of conducting cytogenetic analysis in 

parallel to physical dosimetry in the working place. Teratogenesis Carcinog. 

Mutagen. 21:431-439, 2001. Copyright 2001 Wiley-Liss, Inc."



OK - just my personal comment,



Bjorn Cedervall   bcradsafers@hotmail.com

http://www.geocities.com/bjorn_cedervall/







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