Another (partial) lliterature review

For some reason this just came up on PubMed (indexed 1/10/02). I had

thought Biogerontology had been indexed, but maybe not. A number of

informative papers on aging with in vivo results demonstrating

biopositive effects of radiation and other stressors have been pub'd in

this journal, esp. by Rattan in the Netherlands.

Work funded by NRC! Black hole? Rad protectionists suck in everything

with mass? NRC funded NCRP-136. Could expect NCRP to address the data

(as directed by the Chairman following our presentations in 1996). NCRP

suppressed the data. Only zero-mass science and "the ether" get out!

:-)

Regards, Jim

==========

Biogerontology 2000;1(4):309-19

The effects of gamma rays on longevity.

Calabrese EJ, Baldwin LA.

Department of Environmental Health Sciences, Morrill Science Center,

School of Public Health, University of Massachusetts, Amherst, MA 01003,

USA. edwardc@schoolph.umass.edu

A number of animal model studies have assessed the capacity of long-term

whole body gamma rays to affect life span. The initial goal of such

studies was to establish the equivalent of a no observed adverse effects

level (NOAEL) that would provide a toxicological foundation for deriving

an acceptable worker exposure standard. In the course of initial studies

to establish such a 'tolerance threshold', data emerged suggesting that

low dose rates/cumulative doses enhanced longevity in mice and guinea

pigs of both sexes. Extensive large scale follow-up investigations with

other mouse strains and rats revealed what appear to be

inter-strain/species differences in response with some models providing

strong evidence for a low dose increase in longevity. The subsequent

positive studies in mouse models were generally well designed, well

conducted and used extensive numbers of mice. In all experiments that

displayed enhanced longevity the average life span was enhanced by

10-30% but not the maximum life span potential. The underlying

mechanisms affecting the apparent enhancement in longevity are believed

to result from the stimulation of hematopoietic and immune systems

following an initial low level chronic injury to the bone marrow.

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