Low dose radiation stimulates increased antimutagenic biosystem...

["Bjorn Cedervall" <bcradsafers@hotmail.com>]

I don't have immediate access to the refs. below but a first comment is: An 

alpha particle may cause local damage across a diameter which is larger than 

100 nm. Therefore it seems quite possible that some homologous genes can be 

knocked out by the same ionization (confocal microscopy photographs can give 

you some important clues) - the stage of the cell cycle can be expected to 

be very important. If such a dual knockout occurs there is no "backup" left. 

The same is true for all the events which relate to heterozygosity of 

critical genes (enough to knock out one gene - then there is no backup gene 

to repair from).



Antimutagenic activity can mean a lot of things including increase in the 

amount of thiols in the cell.



Bjorn Cedervall    bcradsafers@hotmail.com

------------------------------------------

"Low dose radiation stimulates increased antimutagenic biosystem activity 

that decreases metabolic mutations, thus lowering cancer mortality and 

increasing longevity." Pollycove M, Feinendegen L, Biologic and 

Epidemiologic Foundations of Radiation Hormesis, J Nucl Med. 42(7),(9). 2001 

and Doctors for Disaster Preparedness 7/14/01, data on tape from 

jersnav@mindspring.com.



Howard Long

-----------

Bjorn Cedervall wrote:



>>4. I BELIEVE the very notion of biological response to any given agent as 

>>linear, clear down to the smallest amount is ridiculous!  Especially when 

>>that agent is and always has been a part of nature.



(PS. For clarity, I did not write the paragraph above/Bjorn Cedervall)

----------------------------------------------------------------------

>Do you agree that irreversible DNA damage can occur due to ionizing

>radiation exposure?

>

>BTW: The most sensitive studies for induction of chromosomal aberrations 

>(micronuclei, Cs-137) show an absolutely straight line down to 2.3 mGy if I 

>recall correctly. The same seems to be true for point mutations in somatic 

>cells with increasing age.





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