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RE: Low dose stimulation produces immunity to cancer
Jim,
Rather than posting more links, please answer my questions regarding the
image at http://cnts.wpi.edu/rsh/Figures/Docs/MP98_fig19.gif. What is the
source of this picture? What is the "science" that supports your claims
based on this study? Let us stick to the current level of knowledge, not
digging up studies that were produced at the beginning of the last century?
Several years ago, we had a discussion of low dose whole body irradiation,
which I found interesting. At that time you asked for an AAPM report on
total and half body photon irradiation, which I supplied. In the article
"The Immunobiology of Low-Dose Total Body Irradiation: More Questions than
Answers," Rad Research 153:599-604 (2000) by Akmal Safwat, that YOU gave me,
it was stated in the abstract "Data from humans, though sparse, suggest that
at least some of these mechanisms occur in patients treated with low-dose
TBI. Whether these immunomodulatory effects are responsible for the
clinical outcome is unclear."
Again, my questions are:
"First and foremost, why do you think that it was the patient's own
immune
system that reduced the size of the tumor? Just because there is a immune
response to the whole body radiation, does that automatically mean that the
reduction in tumor was due to the immune response? Could it have been the
result of the RADIATION? While the tumor may have been outside of the
primary bean, the tumor may have exposed to scatter radiation, which would
depend on the energy and collimation of the field. (Of course, this makes
me wonder about the set up. Generally, you shield the lungs to reduce the
chance of radiophemonitis and not the head during whole and half body
irratiation.) And, no, I do not think it was a transplanted tumor. That
would be silly.
"By the way, why to you point out that radiation is not a drug? Who
said it
was? Are you suggesting that there is a conspiracy not to use radiation by
the medical community? If that is the case, I can assure you that use of
radiation, surgery and drugs all have their place in cancer treatment.
However, for different types of cancers one, different combinations work
better than others. And there are continual evaluations being make on
treatment modalities.
. . .
"I can give you some ideas on what I considered when looking at this
image.
"1. What type of tumor was it? Was it the same type as that one
being
treated that appeared at a different site? If the primary cancer was
sensitive to low dose, dose rate irradiation, so would occurances at
secondary sites as long as it had become malignant.
"2. If is was of a different type, was the tumor malignant of
benign? As a
different tumor type, what type and stage was it at?
"3. Was the tumor complete destroyed or just reduced? There is a
limit to
the resolution of CT imaging, and it may only have been reduced in volume,
but I assume there would have been some mention of this in any patient
follow-up studies. That is why PET is becoming popular in determining
cancer staging and success of colon cancer surgery.
"4. How would you demonstrate that the immune system was destroying
the
tumor? Again, the immune system does respond to stress, like heat as well
as high doses of irraditation. This is the distinction between a casual and
causal effect.
. . .
Sorry of the lenght of this posting and need to repeat my questions.
-- John
John Jacobus, MS
Certified Health Physicist
3050 Traymore Lane
Bowie, MD 20715-2024
E-mail: jenday1@email.msn.com (H)
-----Original Message-----
From: Muckerheide [mailto:muckerheide@attbi.com]
Sent: Monday, October 28, 2002 8:47 AM
To: John Jacobus; radsafe@list.vanderbilt.edu
Subject: Re: Low dose stimulation produces immunity to cancer
on 10/27/02 11:55 AM, John Jacobus at jenday1@MSN.COM wrote:
> Jim, Jim, Jim,
> Why do you doubt that I read what is posted? Because I do not agree with
> YOUR conclusions?
No. Because you don't show any understanding of the science.
For those who are interested in the science before "the demise of a
legitimate hypothesis" (in Ed Calabrese's "kind" published words) in the
1930s, you can see also Pusey in "Science," 1911:
. . .
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