Re: Laymans questions on hormesis and LNT

[John Jacobus <crispy_bird@YAHOO.COM>]

As I said, the devil is in the details. With new

bioassay techniques, we see more details, but are we

closer to a real answer?  I think not. 



We really need to separate the cellular biology from

the population studies.  The latter should determine

the regulations, not the former.



--- BLHamrick@aol.com wrote:

> In a message dated 8/29/2003 2:48:43 PM Pacific

> Standard Time, 

> crispy_bird@YAHOO.COM writes:

> My impression from talking to some researchers is

> that

> the determination of risk is not that the DS breaks

> are or are not repaired, but that they are formed at

> all.  That lowers the threshold even more.  The

> concerns are not that cells die, but are mutated and

> before focus points for cancers.



> Okay, this is not at all my area of expertise, but I

> thought what Cary was 

> saying was that IF they are not repaired, the cell

> dies, so no big deal, and 

> that it is only in the case where a misrepair occurs

> that the risk of cancer 

> increases.  So, it is then critical to understand

> the ratio of cell deaths vs. 

> misrepairs vs. accurate repairs after a DSB event.

> 

> Barbara

> 





=====

-- John

John Jacobus, MS

Certified Health Physicist

e-mail:  crispy_bird@yahoo.com



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