Re: reported side effects from CT scan of head

[John Jacobus <crispy_bird@yahoo.com>]

I think it is important to point out that this in

non-radioactive iodine used in the contrast agent.



--- SiegelB@MIR.WUSTL.EDU wrote:

> 

> Rarely (and I do mean rarely), patients who receive

> iodinated contrast

> material for CT can develop iodine-induced

> hyperthyroidism.  This has

> nothing whatsoever to do with the radiation exposure

> form the CT

> examination.

> 

> The appended reference is an older review article,

> but it will point you in

> the right direction.

> 

> Barry A. Siegel, M.D.

> siegelb@mir.wustl.edu

> 

> 

> Authors

>       Fradkin JE. Wolff J.

> Title

>       Iodide-induced thyrotoxicosis. [Review] [292

> refs]

> Source

>       Medicine. 62(1):1-20, 1983 Jan.

> Local Messages

>       Held by Becker

> Abstract

>       Iodide-induced thyrotoxicosis (IIT) occurs in

> patients with: 1)

>       endemic goiter; 2) nonendemic goiter; 3) no

> previous thyroid disease.

>       Iodine prophylaxis for endemic goiter caused

> transient increase of

>       0.01-0.04% over the basal incidence of

> hyperthyroidism peaking at 1-3

>       years and normalizing in 3-10 years despite

> continued iodide

>       exposure. Elderly subjects with large nodular

> goiters of long

>       standing are at greater risk. In nonendemic

> areas, iodine-containing

>       drugs such as amiodarone, radiographic

> contrast media or

>       iodochlorhydroxyquinoline are implicated in

> IIT more often than

>       iodides. With nonendemic goiter, IIT occurs

> more commonly in women

>       whereas, in the absence of preexisting thyroid

> disease, men are more

>       often affected. In both groups, exophthalmos

> and antithyroid

>       antibodies are absent, radioiodine uptake is

> low, there is no thyroid

>       tenderness or pain, and the hyperthyroidism is

> self-limited (1-6

>       months) and should thus be treated

> conservatively. IIT occurs more

>       frequently in areas of marginal iodine intake

> (Europe) than in the

>       U.S. In view of the extensive exposure to

> iodine, it is a rare

>       complication in this country. It is postulated

> that defective

>       autoregulation of hormone biosynthesis may

> contribute to IIT.

>       [References: 292]

> 

> 

> 

> 





=====

+++++++++++++++++++

"Style is knowing who you are, what you want to say, and not giving a damn"

Gore Vidal



-- John

John Jacobus, MS

Certified Health Physicist

e-mail:  crispy_bird@yahoo.com



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