Re: burns

[John Jacobus <crispy_bird@yahoo.com>]

This is a combined injury effect.  We used to do a lot

of this kind of research with animals at the Armed

Forces Radiobiolgy Research Institute. 

http://www.afrri.usuhs.mil/



The only recent article I could find is:

 Knudson GB, Elliott TB, Brook I, Shoemaker MO, Pastel

RH, Lowy RJ, King GL, Herzig TC, Landauer MR, Wilson

SA, Peacock SJ, Bouhaouala SS, Jackson III WE,

Economos D, Miller AC, Ledney GD (2002) NBC combined

injuries and countermeasures on the battlefield. In:

Seed TM, Blakely WF, Knudson GB, Landauer MR, McClain

DE (eds) Proceedings of the International Conference

on Low-Level Radiation Injury and Medical

Countermeasures, Bethesda, MD, November 8-10, 1999.

Military Medicine, 167(2):95-97.



The effeect is probably not a heightened sensitivity

to radiaiton per se, but synegistis effect due to

suppression of the white cells from both the radiation

and the immune system's response to the burns.  



>From "Medical Management of the Acute Radiation

Syndrome: Recommendations of the Strategic National

Stockpile Radiation Working Group" 

http://www.annals.org/cgi/content/full/140/12/1037



"Lymphopenia is common and occurs before the onset of

other cytopenias. A predictable decline in lymphocytes

occurs after irradiation. In fact, a 50% decline in

absolute lymphocyte count within the first 24 hours

after exposure, followed by a further, more severe

decline within 48 hours, characterizes a potentially

lethal exposure. The predictability of the rate of

lymphocytic depletion count has led to the development

of a model using lymphocyte depletion kinetics as an

element of biodosimetry (30, 31). Patients with burns

(32-34) and trauma (35) may develop lymphopenia as a

result of these injuries alone. Although currently

available predictive models based on absolute

lymphocyte count have been validated (and include

patients with these injuries), it is important to

examine more than one element of biodosimetry whenever

possible."



Check out references 32-34





--- "Stabin, Michael"

<michael.g.stabin@vanderbilt.edu> wrote:



> 

> I just heard in a meeting that if you have thermal

> burns over more than

> 50% of your body, you can have severe marrow

> depression at doses as low

> as 1 Gy. I don't have a reference or anything better

> than "I heard it at

> a meeting". Does anyone have confirmation of this?

> If true, does anyone

> know a mechanism that can explained the apparently

> heightened

> radiosensitivity? Thanks.

> 

> 

> Mike

> 

> Michael G. Stabin, PhD, CHP

> Assistant Professor of Radiology and Radiological

> Sciences 

> Department of Radiology and Radiological Sciences 

> Vanderbilt University 

> 1161 21st Avenue South

> Nashville, TN 37232-2675 

> Phone (615) 343-0068

> Fax   (615) 322-3764

> Pager (615) 835-5153

> e-mail     michael.g.stabin@vanderbilt.edu 

> internet   www.doseinfo-radar.com

> 

>  

>

************************************************************************

> You are currently subscribed to the Radsafe mailing

> list. To

> unsubscribe, send an e-mail to

> Majordomo@list.vanderbilt.edu  Put the

> text "unsubscribe radsafe" (no quote marks) in the

> body of the e-mail,

> with no subject line. You can view the Radsafe

> archives at

> http://www.vanderbilt.edu/radsafe/

> 

> 





=====

+++++++++++++++++++

"The real threat to the life of the nation, in the sense of a people living in accordance with its traditional laws and political values, comes not from terrorism but from laws such as these."

LORD HOFFMAN, of Britain's highest court, which ruled against indefinite detention of terror suspects





-- John

John Jacobus, MS

Certified Health Physicist

e-mail:  crispy_bird@yahoo.com





		

__________________________________ 

Do you Yahoo!? 

Yahoo! Mail - Find what you need with new enhanced search.

http://info.mail.yahoo.com/mail_250