ABSTRACT: . . .Estimate radiation-induced . . . breast cancer in screening programs

[John Jacobus <crispy_bird@yahoo.com>]

  Physics in Medicine and Biology

  Volume 50, 7 February 2005

  http://www.iop.org/EJ/toc/-alert=1462/0031-9155/50/3



. . .



    Use of risk projection models to estimate

mortality and incidence from radiation-induced breast

cancer in screening programs

    M Ramos, S Ferrer, J I Villaescusa, G Verdu', M D

Salas and M D Cuevas

    2005 Phys. Med. Biol. 50 505-520



    Abstract: 

http://www.iop.org/EJ/abstract/-alert=1462/0031-9155/50/3/008



    Full text:

http://www.iop.org/EJ/article/-alert=1462/0031-9155/50/3/008/pmb5_3_008.pdf



    The authors report on a method to calculate

radiological risks, applicable to breast screening

programs and other controlled medical exposures to

ionizing radiation. In particular, it has been applied

to make a risk assessment in the Valencian Breast

Cancer Early Detection Program (VBCEDP) in Spain. This

method is based on a parametric approach, through

Markov processes, of hazard functions for

radio-induced breast cancer incidence and mortality,

with mean glandular breast dose, attained age and

age-at-exposure as covariates. Excess relative risk

functions of breast cancer mortality have been

obtained from two different case-control studies

exposed to ionizing radiation, with different

follow-up time: the Canadian Fluoroscopy Cohort Study

(1950-1987) and the Life Span Study (1950-1985 and

1950-1990), whereas relative risk functions for

incidence have been obtained from the Life Span Study

(1958-1993), the Massachusetts tuberculosis cohorts

(1926-1985 and 1970-1985), the New York post-partum

mastitis patients (1930-1981) and the Swedish benign

breast disease cohort (1958-1987). Relative risks from

these cohorts have been transported to the target

population undergoing screening in the Valencian

Community, a region in Spain with about four and a

half million inhabitants. The SCREENRISK software has

been developed to estimate radiological detriments in

breast screening. Some hypotheses corresponding to

different screening conditions have been considered in

order to estimate the total risk associated with a

woman who takes part in all screening rounds. In the

case of the VBCEDP, the total radio-induced risk

probability for fatal breast cancer is in a range

between [5 x 10-6, 6 x 10-4] versus the natural rate

of dying from breast cancer in the Valencian Community

which is 9.2 x 10-3. The results show that these

indicators could be included in quality control tests

and could be adequate for making comparisons between

several screening programs.

. . .

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=====

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"It doesn't matter whether you're riding an elephant or a donkey if you're going in the wrong direction."

Jesse Jackson





-- John

John Jacobus, MS

Certified Health Physicist

e-mail:  crispy_bird@yahoo.com





		

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