[ RadSafe ] Muller's LNT has misled us!

[John Jacobus]

I would say that the LNT is a good model for the fruit
fly germ cell, but not for human epidemiological
studies.  Does that sound appropriate?

--- "Otto G. Raabe" <ograabe at ucdavis.edu> wrote:
> April 14, 2005
> 
> We all learned in the study of radiation biology
> that Muller observed a 
> perfect LNT relationship for simple ionizing
> radiation (x ray) mutations 
> in  Drosophila fruit flies (H.J. Muller, SCIENCE 66:
> 84-87, 1927). That 
> observation was for Drosophila spermatozoa (see
> Spencer and Stern, 1948). 
> However,  new research using somatic cells rather
> then germ cells shows 
> that those results probably do NOT apply to
> carcinogenesis!
> 
> T. Koana, Y. Takashima, M.O. Okada, M. Ikehata, J.
> Miyakoshi, and K. Sakai, 
> A Threshold Exists in the Dose-Response Relationship
> for Somatic Mutation 
> Frequency Induced By X Irradiation of Drosophila,
> RADIATION RESEARCH 161, 
> 391-396 (2004), show not only a threshold below 1
> Gy, but also a reduction 
> (hormesis?) below 0.5 Gy for some alterations. The
> simple  changes observed 
> by Muller in germ cells do not apply to somatic
> cells. These new results 
> indicate that LNT probably does not apply to 
> carcinogenesis at low doses.
> 
> In any case, we can now see why Muller's results are
> not applicable to the 
> LNT debate.
> 
> Otto
> 
> 
> 
> **********************************************
> Prof. Otto G. Raabe, Ph.D., CHP
> Center for Health & the Environment
> (Street Address: Bldg. 3792, Old Davis Road)
> University of California, Davis, CA 95616
> E-Mail: ograabe at ucdavis.edu
> Phone: (530) 752-7754   FAX: (530) 758-6140
> ***********************************************  
> 
> 

+++++++++++++++++++
"Embarrassed, obscure and feeble sentences are generally, if not always, the result of embarrassed, obscure and feeble thought."
Hugh Blair, 1783

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com


		
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