[ RadSafe ] Cancer related gene p53 not regulated as indicated by previous ti ssue culture research; results may be relevant to drug development

[John Jacobus]

As I have said before, biology is not like physics.

--- Roy.Herren at med.va.gov wrote:

> http://www.salk.edu/news/releases/details.php?id=136
> 
> Cancer related gene p53 not regulated as indicated
> by previous tissue
> culture research; results may be relevant to drug
> development 
> 
> June 27, 2005 
> La Jolla, CA - The cellular cascade of molecular
> signals that instructs
> cells with fatally damaged DNA to self-destruct
> pivots on the p53 tumor
> suppressor gene. If p53 is inactivated, as it is in
> over half of all human
> cancers, checks and balances on cell growth fail to
> operate, and body cells
> start to accumulate mutations, which ultimately may
> lead to cancer. Not
> surprisingly, the regulation of this vital safeguard
> has been studied in
> great detail for many years but mainly in tissue
> culture, or in vitro,
> models. 
> . . .

+++++++++++++++++++
"Every now and then a man's mind is stretched by a new idea and never shrinks back to its original proportion." -- Oliver Wendell Holmes, Jr.

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com

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