Re: Pu Toxicity

[Joshua.W.Hamilton@Dartmouth.EDU (Joshua W. Hamilton)]

regarding Don Jordan's posting:

That LD-50 for botulinus toxin is wrong.  It's usually considered to be
around 0.00001 mg/kg in rodents, i.e., 0.01 ug/kg , not e-9 ug/kg.  That's
still super-toxic.  By comparison, the LD-50 for dioxin, often called the
"most toxic small molecule," is 100-fold greater at around 0.001 mg/kg in
rodents.  But as pointed out, we're comparing apples and oranges since acute
lethality isn't really the issue with plutonium (or dioxin).

Joshua Hamilton Ph.D.
Dept. Pharmacology & Toxicology
Dartmouth Medical School