KI Inquiry

["Thompson, Donald L. 827-0012" <DLT@FDADR.CDRH.FDA.GOV>]

This EM is response to inquiry on use of potassium iodide (KI) in radiological 
accidents.  The U. S. Food and Drug Administration (FDA) published guidance on 
use of the drug as a prophylactic for the thyroid when projected doses to the 
gland reach 25 rem or more.  Administer 130 mg KI to adults, and to children 1 
year or older, daily during exposure.  For maximum effectiveness, administer 
immediately before or after exposure begins, but it will have substantial 
effect if given up to four hours after an acute exposure.

Note that a small percentage of the population may have an adverse reaction to 
the drug, e.g. nausea or a metallic taste, of mild and transient nature.  
However, an even smaller percentage may have a severe and life-threatening 
reaction requiring prompt medical attention.  It is wise to have a physician 
involved in your planning and decision to distribute KI.

For a copy of the FDA recommendations, or other info, send me your postal 
address or fax number at DLT@FDADR.CDRH.FDA.GOV.  You may also call me in 
Maryland at (301) 827-0012.