Re: Tritiate organic compounds via irradiation?

["Charles Meyer" <cmeyer@brc1.tdh.state.tx.us>]

> Date:          Fri, 26 Sep 97 10:28:22 -0500
> Reply-to:      radsafe@romulus.ehs.uiuc.edu
> From:          Tom Paquette <Tom.Paquette@usa.net>
> To:            Multiple recipients of list <radsafe@romulus.ehs.uiuc.edu>
> Subject:       Tritiate organic compounds via irradiation?

> Radsafers:
> 	Is it possible and reasonable to label organic compounds by neutron =
> bombardment?  I need to label mg. to g. quantities of a compound with =
> tritium and could do this in 10-30% yield with available reagents to =
> produce a molecule with alkyl T's that are not exchangeable in aqueous =
> solution.  I suppose that is the way to do this but the question has =
> arisen whether or not alternatives are possible.  The reliability of the =
> synthesis on small scale is uncertain, particularly if we elect to use =
> an outside labeling group.  Any comments?  Thanks.
> 
> Tom Paquette
> Univera Pharmaceuticals
> Broomfield, CO 80021
>
You could but, depending on cross sections, you'd be labeling with a 
lot of other radioisotopes of the other elements forming the 
compounds in the solution. 
<><><><><><><><><><><><><><><><><>            
<>    Charles R. (Russ) Meyer                  <>
<> Email: cmeyer@brc1.tdh.state.tx.us           <> 
<>     Phone:(512)834-6688                       <>
<>        Fax:(512)834-6654                        <>
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