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Re: The word according to ORISE on DTPA


Scott, 
We just got a new shipment of Zn-DTPA and Ca-DTPA in as out other batch was
expired..This is what the informational pack indicates for Contraindications;

Ca-DTPA treatment is contraindicated for minors, pregnant women, patients
with nephroic syndrome, and in paitents with bone marrow depression. (Such
paients may be treated with Zn-DATP.) Ca-DTPA or Zn-DTPA should not be used
as a chelator for uranium or neptunium. Internal contamination with uranium
is currently treated by alkalizing the urine with bicarbonate in order to
promote excretion. DTPA has also been postulated to form and unstable
complex with neptunuim, which may cause bond deposition of this actinide.

Hope this helps
Bob






At 11:38 AM 9/2/99 -0500, you wrote:
>At 07:41 AM 9/2/99 -0500, you wrote:
>>I am searching for current/recent information on the side effects of DTPA
>>administered for radionuclide uptakes.  If you have any information, or can
>>point me in the right direction, please let me know.
>>
>>M. Scott Osborn
>>RFETS
>>BLDG T130B
>>Phone: (303)966-5670
>>Pager: (303)212-4660
>>Email: scott.osborn@rfets.gov
>>************************************************************************
>>The RADSAFE Frequently Asked Questions list, archives and subscription
>>information can be accessed at http://www.ehs.uiuc.edu/~rad/radsafe.html
>>
>
>Dear Scott:
>
>If you are referring to Zn and Ca DTPA to treat transuranic poisoning,
>contact Dr. Ron Goans at REAC/TS.  He runs the IND.  (423)576-3131 is his
>phone.  The area code changes to 865 after Oct. 1, 1999.
>
>Ciao, Carol
>
>csmarcus@ucla.edu
>
>************************************************************************
>The RADSAFE Frequently Asked Questions list, archives and subscription
>information can be accessed at http://www.ehs.uiuc.edu/~rad/radsafe.html
>
>

Robert L. Sarason
EH&S TB 30
U.C.Davis
Health and Safety Specialist
Laser Safety Officer
Davis, Ca. 95616
530-752-3737
Fax 530-752-4527
rlsarason@ucdavis.edu
************************************************************************
The RADSAFE Frequently Asked Questions list, archives and subscription
information can be accessed at http://www.ehs.uiuc.edu/~rad/radsafe.html