RE: Measurement and Calculation of Beta Emitter Radiopharmaceutical

["Beasley, Charles W." <CWBeasley@sprg.smhs.com>]

You could try a local radiopharmacy and order the 3.2 mCi.  Or you can use
the manufacturer's activity and volume to calculate the volume required to
give the 3.2 mCi.  Then you can use the dosecalibrator as a verification
check to the calculated method.

Charles Beasley
St. John's Regional Health Center
Springfield, MO

> ----------
> From: 	Robert A Scott[SMTP:bobscottchp@juno.com]
> Reply To: 	radsafe@romulus.ehs.uiuc.edu
> Sent: 	Wednesday, December 08, 1999 14:38
> To: 	Multiple recipients of list
> Subject: 	Measurement and Calculation of Beta Emitter
> Radiopharmaceutical
> 
> Radsafers:
> 
> 	In RI we have just received the revised regulations of the Radiation
> Control Agency.  And one of our docs wants to treat a patient with sodium
> phosphate (P-32) for polycythemia vera.  The order is for 3.2 mCi, but
> vendors only supply in 5 mCi (5 ml) vials or syringe.  Are there any
> vendors out there who supply unit doses of sodium phosphate (P-32)?  The
> new regs say that if I cannot obtain a unit dose, I have to be able to
> measure or measure and calculate the dose using some method other than a
> simple comparison technique with a photon dose calibrator.  Then whatever
> method I use, I have to document and describe the assay technique and
> hold this documentation for 3 years.
> 
> 	I thought of a basic internal standard liquid scintillation
> technique,
> but such standards are not routinely available anytime we want.  
> 
> 	So how do we do this?  Or am I interpreting this regulation too
> literally?  Any help will be greatly appreciated.
> 
> Bob Scott, RPO 
> Roger Williams Medical Center
> Providence, Rhode Island
> bobscottchp@juno.com
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