RE: Measurement and Calculation of Beta Emitter Radiopharmaceutic

["Jean-Francois, Stephane" <stephane_jeanfrancois@merck.com>]

In at least two posting, people are talking about dose calibrators.

Can I express my desire to learn more about nuclear medicine and ask how a
dose calibrator works for P-32 ? (being a Beta emittor).

Also, if the supplier is assuring you fo a certain activity of P-32 at the
calibration date for a serynge, can't you simply wait for decay
(calculation)and inject the stuff, assuming a certain error ? (Again I don't
know enough on nuclear medicine to figure it out by myself.)

Just curiosity...

Stephane Jean-Francois, Eng., CHP

Specialiste en radioprotection/Radiation Safety Specialist
Gestion des risques/Risk Management
Merck Frosst Canada & Co
TEL: 514.428.8695
FAX; 514.428.8541
email: stephane_jeanfrancois@merck.com 


-----Original Message-----
From: Rotman Mark [mailto:MRotman@snm.org]
Sent: Wednesday, December 08, 1999 4:04 PM
To: Multiple recipients of list
Subject: RE: Measurement and Calculation of Beta Emitter
Radiopharmaceutic
 CUT

....determine
mathematically its theoretical activity based on the manufacturers assay,
and adjust the pot setting on your dose calibrator until you get a read out
that matches.  

CUT

Mark Rotman
Government Relations
Society of Nuclear Medicine
703-708-9000 ext. 1242
703-708-9777 FAX
mrotman@snm.org
http://www.snm.org



-----Original Message-----
From: Robert A Scott [mailto:bobscottchp@juno.com]
Sent: Wednesday, December 08, 1999 3:36 PM
To: Multiple recipients of list
Subject: Measurement and Calculation of Beta Emitter Radiopharmaceutical


Radsafers:

	In RI we have just received the revised regulations of the Radiation
Control Agency.  And one of our docs wants to treat a patient with sodium
phosphate (P-32) for polycythemia vera.  The order is for 3.2 mCi, but
vendors only supply in 5 mCi (5 ml) vials or syringe.  Are there any
vendors out there who supply unit doses of sodium phosphate (P-32)?  The
new regs say that if I cannot obtain a unit dose, I have to be able to
measure or measure and calculate the dose using some method other than a
simple comparison technique with a photon dose calibrator.  Then whatever
method I use, I have to document and describe the assay technique and
hold this documentation for 3 years.

	I thought of a basic internal standard liquid scintillation
technique,
but such standards are not routinely available anytime we want.  

	So how do we do this?  Or am I interpreting this regulation too
literally?  Any help will be greatly appreciated.

Bob Scott, RPO 
Roger Williams Medical Center
Providence, Rhode Island
bobscottchp@juno.com
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