[ RadSafe ] Re: Universal Hormesis mechanisms in vivo?

Sun Nov 6 04:00:15 CST 2005

Jim is quite right in his reasoning and it is backed by experiments. Ludwig

----- Original Message ----- 
From: "Muckerheide, James" <jimm at WPI.EDU>
To: "John Jacobus" <crispy_bird at yahoo.com>; "howard long" 
<hflong at pacbell.net>
Cc: "radsafe" <radsafe at radlab.nl>; <rad-sci-l at WPI.EDU>
Sent: Friday, November 04, 2005 7:58 PM
Subject: RE: [ RadSafe ] Re: Universal Hormesis mechanisms in vivo?

> Hi John,
>
> You are right, but this relates to the point we've been making for 10 
> years
> or so:  The biological responses to stresses are intrinsic to biology.
>
> Stress response is not unique to each stressor.  The stress protein HSP70
> (heat shock protein) is stimulated in many cases.  It is also shown to 
> apply
> to heat, and exercise, and to many psychological stresses, and to heavy
> metals, etc., etc.
>
> It would be unlikely (or unbelievable) if biology responded differently to
> radiation, with stimulation at low doses and suppression at high doses. 
> (Not
> all suppression is "bad," e.g., heavy exercise in the damage-repair 
> regime,
> and not all stimulation is "good."  But we know that the specific 
> responses
> to radiation are generally a net-positive effect on the biological and
> physiological functions of an organism - and why cellular studies are
> generally irrelevant to understand low vs. high dose effects to an 
> organism,
> even though it may be informative about (some) mechanisms.)
>
> It is also the case that the stimulation of specific genes, proteins,
> enzymes, and effects on immune cells, etc. are entirely DIFFERENT when
> exposed to a low dose vs. a high dose.  In some cases the response at a 
> low
> dose is stimulated vs. suppressed, or the opposite; and in some cases 
> totally
> different genes are stimulated at high vs. low doses.  This means that a
> biological "linearity" isn't possible, with responses 'similar' but 
> reduced
> at low vs. high doses.  Biological and physiological responses are 
> entirely
> different in immunological whole organisms at low vs. high doses.
>
> Remember Murphy (PNAS 1920) stimulating vs. suppressing lymphocytes at 
> lower
> vs. higher doses? Causing dramatic decreases instead of increases of 
> cancers
> vs. controls:
> http://cnts.wpi.edu/rsh/DD3/Murphy20PNASResistMiceCa!.pdf
> (just a couple of pages).
>
> Regards, Jim
>
>
>> -----Original Message-----
>> From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On
>> Behalf Of John Jacobus
>> Sent: Friday, November 04, 2005 1:28 PM
>> To: howard long
>> Cc: radsafe; rad-sci-l at WPI.EDU
>> Subject: [ RadSafe ] Re: Universal Hormesis mechanisms in vivo?
>>
>> Howard,
>> Antigens are biological and alpha-benzene
>> hydrochloride is a chemical.  Ionizing radiation is a
>> form of energy.  The response may not be the same.
>>
>> I assumed that you knew the differences.  By the way,
>> you do know about the placebo effect?
>>
>> --- howard long <hflong at pacbell.net> wrote:
>>
>> > Allergy shots (very low dose of antigens known to be
>> > poison to that person)
>> > like low dose alpha-benzene hydrochloride (below,
>> > even sounds toxic),
>> > like low dose ionizing radiation (the subject of
>> > this site)
>> > demonstrate that hormesis is universal in biology,
>> > NOT LNT!
>> >
>> > Beir 7 LNT propagandists should be treated like
>> > persons perpetuating flat-earth dogma.
>> >
>> > I am not aware of the effect of LDR on asthma.
>> > Maybe Pat Lewis of Health Mines (radon) has
>> > anecdotes.
>> > She is looking for a study there.
>> >
>> > Howard Long
>> >
>> > John Jacobus <crispy_bird at yahoo.com> wrote:
>> > Howard,
>> > Why did you send this to me? Are you claiming that
>> > radiation can be used against allergies from pollen
>> > and ragweed? That certain is a new claim? Do you
>> > have any proof of this?
>> >
>> > --- howard long wrote:
>> >
>> > >
>> > >
>> > > howard long wrote:Date: Thu, 3
>> > > Nov 2005 11:12:00 -0800 (PST)
>> > > From: howard long
>> > > Subject: Re: Hormesis mechanisms in vivo
>> > > To: "Ludwig E. Feinendegen" ,
>> > > "Muckerheide, James" ,
>> > > "rad-sci-l at wpi.edu"
>> > >
>> > > Allergy Treatmant Uses Hormesis.
>> > >
>> > > All physicians who use desensitization for
>> > allergy,
>> > > use hormesis.
>> > > We inject miniscule, increasing doses twice weekly
>> > > of the same antigens (like pollen)
>> > > which cause inflammation on application to skin
>> > > scratch.
>> > >
>> > > Asthma and hayfever when found to be from a
>> > specific
>> > > antigen (like walnut pollen in my case)
>> > > are markedly relieved by this treatment, standard
>> > > for half a century.
>> > >
>> > > With LNT, one would expect slight worsening of
>> > > symptoms like wheeze or watery eyes,
>> > > when low dose of the toxin is applied.
>> > > Hormesis, not LNT, is the usual biologic response
>> > to
>> > > toxins like radiation and pollen.
>> > > Beir 7 procamation of LNT is like, "Flat earth!"
>> > > Treat its advocates accordingly.
>> > >
>> > > Howard Long
>> > >
>> > >
>> > > wrote:
>> > > st1\:* { BEHAVIOR: url(#default#ieooui)}Thanks,
>> > Jim.
>> > > This is another encouraging paper and puts our
>> > work
>> > > into broader perspectives. All the best, Ludwig
>> > > ----- Original Message -----
>> > > From: Muckerheide, James
>> > > To: rad-sci-l at wpi.edu
>> > > Sent: Thursday, October 27, 2005 5:00 PM
>> > > Subject: Hormesis mechanisms in vivo
>> > >
>> > >
>> > >
>> > > Friends,
>> > >
>> > >
>> > >
>> > > This further indicates a consistent response
>> > between
>> > > chemical and radiation exposures, further
>> > > establishing 'hormesis' as a fundamental principle
>> > > in biology.
>> > >
>> > >
>> > >
>> > > I do not have access to this journal.
>> > >
>> > >
>> > >
>> > > Regards, Jim Muckerheide
>> > >
>> > > ===================
>> > >
>> > >
>> > >
>> > > Cancer Lett. 2005 Oct 21; [Epub ahead of print]
>> > >
>> > >
>> > >
>> > > Alpha-benzene hexachloride exerts hormesis in
>> > > preneoplastic lesion formation of rat
>> > > hepatocarcinogenesis with the possible role for
>> > > hepatic detoxifying enzymes.
>> > >
>> > > Puatanachokchai R, Morimura K, Wanibuchi H, Oka M,
>> > > Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y,
>> > > Fukushima S
>> > >
>> > > Department of Pathology, Osaka City University
>> > > Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka
>> > > 545-8585, Japan.
>> > >
>> > > Recently there has been a shift in the prevailing
>> > > paradigm regarding the dose dependence of
>> > carcinogen
>> > > action with increasing acceptance of hormesis
>> > > phenomenon, although underlying mechanisms remain
>> > to
>> > > be established. To ascertain whether alpha-benzene
>> > > hexachloride (alpha-BHC) might act by hormesis,
>> > rats
>> > > were initiated with diethylnitrosamine and then
>> > > alpha-BHC ranging from 0.01 to 500 ppm was
>> > > administered in the diet for 10 weeks. The highest
>> > > concentration of alpha-BHC significantly increased
>> > > the number and area of glutathione S-transferase
>> > > placental form (GST-P) positive foci,
>> > preneoplastic
>> > > lesions in the liver, but its low! dose, 0.05ppm,
>> > > caused significant reduction, showing a J-shape
>> > > dose-response curve. The proliferating cell
>> > nuclear
>> > > antigen positive index for GST-P positive foci in
>> > > the low dose-treated group was significantly
>> > > reduced. The dose response curves of CYP450
>> > content,
>> > > NADPH-P450 reductase activity and
>> > > 8-hydroxydeoxyguanosine formation revealed the
>> > same
>> > > pattern as
>> > > GST-P positive foci data. The response curves of
>> > > CYP2B1 and 3A2 in their activities, protein and
>> > mRNA
>> > > expression showed a threshold but CYP2C11 activity
>> > > exhibited an inverted J-shape. These results might
>> > > suggest the possibility of hormesis of alpha-BHC
>> > at
>> > > early stages of rat hepatocarcinogenesis. The
>> > > possible mechanism involves induction of
>> > detoxifying
>> > > enzymes at low dose, influencing free radical
>> > > production and oxidative stress, and consequently
>> > > pathological change in the liver.
>> > >
>>
>>
>> +++++++++++++++++++
>> On Oct. 5, 1947, in the first televised White House address, President
>> Truman asked Americans to refrain from eating meat on Tuesdays and 
>> poultry
>> on Thursdays to help stockpile grain for starving people in Europe.
>>
>> -- John
>> John Jacobus, MS
>> Certified Health Physicist
>> e-mail:  crispy_bird at yahoo.com
>>
>>
>>
>>
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> 