[ RadSafe ] References: Radiation induced immune response DETERS spread of cancer

[howard long]

  Health Physicists,
   
  The following recent exchange on Rad-Sci will help rad-safe participants to position themselves for the coming use of 1 to 10 rads to prevent cancer. Pollycove and Feinendigan have shown in cell and mouse studies that radiation blocks 9 ORDERS of magnitude more mutations than it causes. The speculations presented by Jacobus below show the stimulus, but not the 1,000,000,000 x biologic defense response!     
  Howard Long
   
  From: ?lt;i>howard long <hflong at pacbell.net>
To: ?lt;i>christoph.koestinger at gmx.net, rad-sci-l at WPI.EDU
CC: ?lt;i>"'Dietrich Harder'" <d.b.harder at gmx.de>
Subject: ?lt;i>Radon, anti-inflammatory medicines and the immunesystem
Date: ?lt;i>Mon, 3 Jul 2006 09:40:09 -0700 (PDT)

Thank you, Dietrich Harder and Christopher Koestinger for this biologic explanation of radon improvement of arthritis. Radon certainly is safer, as you use it, than our non-steroidal antiinflammatory drugs and corticoids, as we must use them.
?
?lt;/div> ?lt;br> This should be publicized to enable use of radon by a propagandized public.
?
Radon removers and regulators disinform to perpetuate their useless and damaging occupations.
?
?lt;/div> ?lt;br> Howard Long, family doctor, epidemiologist

Christoph Köstinger <christoph.koestinger at gmx.net> wrote:
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  ??lt;br> ?
I forwarded the below discussion to Prof. Harder, University Goettingen, who is one of 
the authors of the recent published book "Radon als Heilmittel" and I would like to forward his answer now.
?
Christoph Koestinger
Gasteiner Heilstollen, Austria
?lt;br> ?lt;/div> ?lt;br> Dear friends,
?lt;br> thank you for sending me some questions concerning the treatment of rheumatic arthritis with radon. According to present insight, the anti-inflammatory action mechanism of alpha particles, mediated by low alpha-particle doses in epithelial tissues, is a three-stage mechanism:
?lt;br> a) Deposition of the radon daughter products in the corneal layer of the skin (bath treatment, treatment in caves) respectively in the lung epithelium (treatment in caves). The enhanced 
solubility of radon gas in fatty tissues is true, but does only play a marginal role.
?
b) Alpha-particle induced production of apoptotic cells in the epithelia at low doses, supported by the bystander effect.
?lt;br> c) Mediation of an anti-inflammatory immune response, triggered by the phagocytosis of the apoptotic cells by dendritic cells, e.g. the Langerhans cells. This process can be called a modification of the immune response rather than an enhancement of the immune response. The word "enhancement" however is not incorrect when referred to the enhanced maturation of immature dendritic cells and the enhanced activation of anti-inflammatory cytokines.
?lt;br> The applied doses are so low that a complete annual treatment course does not more than double the normal natural radiation exposition of the human body, when 
expressed in terms of the effective dose per year.
?
The great advantage of the anti-inflammatory treatment with radon lies in the long-time reduction of the administration of anti-inflammatory drugs which have numerous side effects.
?lt;br> I have described this mechanism in a chapter of the book "Radon als Heilmittel", edited by RADIZ Schlema and published by Dr.Kovac, Hamburg (ISSN 1435-6309, ISBN 3-8300-1768-5). The special question how the alpha particles, emitted by radon daughters deposited deep in the corneal layer of the skin, can reach epithelial cell layers containing Langerhans cells is being treated in biophysical experiments of Prof.
?lt;br> von Philipsborn, and the results will be presented in a specialized scientific symposium, the "4th Biophysikalische Arbeitstagung" in Bad Schlema (Germany), Sept. 22 - 
24, 2006; informations by our bureau radizev at t-online.de.
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With kindest regards, Dietrich Harder.


John Jacobus <crispy_bird at yahoo.com> wrote:  Dr. Long,
Your preferences are your choices. I think that
researchers who study cancer should not be discounted
even if they do not studies do not align with your
beliefs. Obviously you need to keep up with the
research literate. Macrophages are not dendritic
cells, and as a physician I would think that you would
know that. My point is that the biology of cancer is
very complex and treatments are not as simplistic as
you think.

Again, you can only quote the speculations of Dr.
Chen, who even acknowledges that his work was never
followed up. 

--- howard long wrote:

> Prof Dietrich Harder of U Goettingen describes the
> mechanism recently on rad-sci:
> 
> "- production of apoptotic cells in the epithelia
> at low doses, supported by the bystander effect.
> Mediation of an anti-inflammatory immune response,
> triggered by the phagocytosis of the apoptotic cells
> by dendritic cells, e.g. the Langerhans cells. This
> process can be called a modification of the immune
> response rather than an enhancement of the immune
> response. The word "enhancement" however is not
> incorrect when referred to the enhanced maturation
> of immature dendritic cells and the enhanced
> activation of anti-inflammatory cytokines.
> The applied doses are so low that a complete annual
> treatment course does not more than double the
> normal natural radiation exposition of the human
> body, when 
> expressed in terms of the effective dose per year"
> 
> I was referred to this by Prof Feinendigan who,
> with Prof Pollycove has done the most in this area,
> as in The Biologic and Epidemiologic Basis for
> Radiation Hormesis, presented to and critiqed by
> Doctors for Disaster Preparedness.
> 
> Far from worsening cancer patients, low dose
> radiaion
> stimulation of apoptosis, phagocytosis and the
> immune system generally, brings healing - NOT the
> more rapid cancer growth implied by this Jacobus
> selection, as could be found in numerous references
> through Muckerheides compendium.
> For prevention, see,
> Is Chronic Radiation anEffective Prophylaxis
> Against Cancer? 
> Chen, WL, Luan, YC, et al Journal Am Physicians
> and Surgeons 9:1:6-10
> 
> Howard Long MD MPH
> 
> John Jacobus wrote:
> One of the arguements used to tout the benefits of
> low
> dose ionizing radiation is that it enhances immune
> response. I thought the following was interesting.
> -----------------------
> >From the NYT Health section
>
http://www.nytimes.com/2006/08/15/health/15meta.html?ei=5070&en=43242bd64ec6e9b0&ex=1156651200&pagewanted=all
> 
> Scientists Begin to Grasp the Stealthy Spread of
> Cancer 
> 
> By LAURIE TARKAN
> Published: August 15, 2006
> 
> . . .
> Researchers are looking at a number of events that
> occur in the microenvironment that give a cancer
> cell
> a leg up as soon as it arrives. These changes
> involve
> both normal cells that reside in that tissue and the
> body’s roaming immune cells. 
> 
> “The tumor cells co-opt these cells to act in a way
> that’s conducive for the growth of the metastasis,”
> Dr. Massagué said.
> 
> There is evidence, for example, that a type of white
> blood cell, the macrophage, may help initiate
> colonization. It was once thought that high numbers
> of
> macrophages found in metastatic cancer colonies were
> there to do battle with the cancer. Now it is
> believed
> that they somehow promote factors that help tumors
> progress. Other normal cells are believed to make
> enzymes that loosen the cellular structure of the
> new
> host organ, making room for tumor cells to
> proliferate. 
> . . .
> 
>