[ RadSafe ] Re: References: Radiation induced immune response DETERS spread of cancer

Sat Aug 26 21:05:58 CDT 2006

Dr. Long,
1.  What does the radon and arthritis have to do with
the discussion of low-dose radiation and cancer? 
Apparently if you do not have any good arguments, you
just throw something into the discussin?

2.  If radiation is so beneficial, what have Drs.
Pollycove and Feinendigan done to enhance their
radiation exposures?  Have they moved to areas where
there is more background radiation?

Can you cite some references in the literature that
these claims are true?  Are there any statistics on 
humans that support this claim? 

As I said:
Your preferences are your choices. I think that
researchers who study cancer should not be discounted
even if they do not studies do not align with your
beliefs. 

--- howard long <hflong at pacbell.net> wrote:

>   Health Physicists,
>    
>   The following recent exchange on Rad-Sci will help
> rad-safe participants to position themselves for the
> coming use of 1 to 10 rads to prevent cancer.
> Pollycove and Feinendigan have shown in cell and
> mouse studies that radiation blocks 9 ORDERS of
> magnitude more mutations than it causes. The
> speculations presented by Jacobus below show the
> stimulus, but not the 1,000,000,000 x biologic
> defense response!     
>   Howard Long
>    
>   From: ?lt;i>howard long <hflong at pacbell.net>
> To: ?lt;i>christoph.koestinger at gmx.net,
> rad-sci-l at WPI.EDU
> CC: ?lt;i>"'Dietrich Harder'" <d.b.harder at gmx.de>
> Subject: ?lt;i>Radon, anti-inflammatory medicines
> and the immunesystem
> Date: ?lt;i>Mon, 3 Jul 2006 09:40:09 -0700 (PDT)
> 
> Thank you, Dietrich Harder and Christopher
> Koestinger for this biologic explanation of radon
> improvement of arthritis. Radon certainly is safer,
> as you use it, than our non-steroidal
> antiinflammatory drugs and corticoids, as we must
> use them.
> ?
> ?lt;/div> ?lt;br> This should be publicized to
> enable use of radon by a propagandized public.
> ?
> Radon removers and regulators disinform to
> perpetuate their useless and damaging occupations.
> ?
> ?lt;/div> ?lt;br> Howard Long, family doctor,
> epidemiologist
> 
> Christoph Köstinger <christoph.koestinger at gmx.net>
> wrote:
> ?
> 
>   ??lt;br> ?
> I forwarded the below discussion to Prof. Harder,
> University Goettingen, who is one of 
> the authors of the recent published book "Radon als
> Heilmittel" and I would like to forward his answer
> now.
> ?
> Christoph Koestinger
> Gasteiner Heilstollen, Austria
> ?lt;br> ?lt;/div> ?lt;br> Dear friends,
> ?lt;br> thank you for sending me some questions
> concerning the treatment of rheumatic arthritis with
> radon. According to present insight, the
> anti-inflammatory action mechanism of alpha
> particles, mediated by low alpha-particle doses in
> epithelial tissues, is a three-stage mechanism:
> ?lt;br> a) Deposition of the radon daughter products
> in the corneal layer of the skin (bath treatment,
> treatment in caves) respectively in the lung
> epithelium (treatment in caves). The enhanced 
> solubility of radon gas in fatty tissues is true,
> but does only play a marginal role.
> ?
> b) Alpha-particle induced production of apoptotic
> cells in the epithelia at low doses, supported by
> the bystander effect.
> ?lt;br> c) Mediation of an anti-inflammatory immune
> response, triggered by the phagocytosis of the
> apoptotic cells by dendritic cells, e.g. the
> Langerhans cells. This process can be called a
> modification of the immune response rather than an
> enhancement of the immune response. The word
> "enhancement" however is not incorrect when referred
> to the enhanced maturation of immature dendritic
> cells and the enhanced activation of
> anti-inflammatory cytokines.
> ?lt;br> The applied doses are so low that a complete
> annual treatment course does not more than double
> the normal natural radiation exposition of the human
> body, when 
> expressed in terms of the effective dose per year.
> ?
> The great advantage of the anti-inflammatory
> treatment with radon lies in the long-time reduction
> of the administration of anti-inflammatory drugs
> which have numerous side effects.
> ?lt;br> I have described this mechanism in a chapter
> of the book "Radon als Heilmittel", edited by RADIZ
> Schlema and published by Dr.Kovac, Hamburg (ISSN
> 1435-6309, ISBN 3-8300-1768-5). The special question
> how the alpha particles, emitted by radon daughters
> deposited deep in the corneal layer of the skin, can
> reach epithelial cell layers containing Langerhans
> cells is being treated in biophysical experiments of
> Prof.
> ?lt;br> von Philipsborn, and the results will be
> presented in a specialized scientific symposium, the
> "4th Biophysikalische Arbeitstagung" in Bad Schlema
> (Germany), Sept. 22 - 
> 24, 2006; informations by our bureau
> radizev at t-online.de.
> ?
> With kindest regards, Dietrich Harder.
> 
> 
> John Jacobus <crispy_bird at yahoo.com> wrote:  Dr.
> Long,
> Your preferences are your choices. I think that
> researchers who study cancer should not be
> discounted
> even if they do not studies do not align with your
> beliefs. Obviously you need to keep up with the
> research literate. Macrophages are not dendritic
> cells, and as a physician I would think that you
> would
> know that. My point is that the biology of cancer is
> very complex and treatments are not as simplistic as
> you think.
> 
> Again, you can only quote the speculations of Dr.
> Chen, who even acknowledges that his work was never
> followed up. 
> 
> --- howard long wrote:
> 
> > Prof Dietrich Harder of U Goettingen describes the
> > mechanism recently on rad-sci:
> > 
> > "- production of apoptotic cells in the epithelia
> > at low doses, supported by the bystander effect.
> > Mediation of an anti-inflammatory immune response,
> > triggered by the phagocytosis of the apoptotic
> cells
> > by dendritic cells, e.g. the Langerhans cells.
> This
> > process can be called a modification of the immune
> > response rather than an enhancement of the immune
> > response. The word "enhancement" however is not
> > incorrect when referred to the enhanced maturation
> > of immature dendritic cells and the enhanced
> > activation of anti-inflammatory cytokines.
> > The applied doses are so low that a complete
> annual
> > treatment course does not more than double the
> > normal natural radiation exposition of the human
> > body, when 
> > expressed in terms of the effective dose per year"
> > 
> > I was referred to this by Prof Feinendigan who,
> > with Prof Pollycove has done the most in this
> area,
> > as in The Biologic and Epidemiologic Basis for
> > Radiation Hormesis, presented to and critiqed by
> > Doctors for Disaster Preparedness.
> > 
> > Far from worsening cancer patients, low dose
> > radiaion
> > stimulation of apoptosis, phagocytosis and the
> > immune system generally, brings healing - NOT the
> > more rapid cancer growth implied by this Jacobus
> > selection, as could be found in numerous
> references
> > through Muckerheides compendium.
> > For prevention, see,
> > Is Chronic Radiation anEffective Prophylaxis
> > Against Cancer? 
> > Chen, WL, Luan, YC, et al Journal Am Physicians
> > and Surgeons 9:1:6-10
> > 
> > Howard Long MD MPH
> > 
> > John Jacobus wrote:
> > One of the arguements used to tout the benefits of
> > low
> > dose ionizing radiation is that it enhances immune
> > response. I thought the following was interesting.
> > -----------------------
> > >From the NYT Health section
> >
>
http://www.nytimes.com/2006/08/15/health/15meta.html?ei=5070&en=43242bd64ec6e9b0&ex=1156651200&pagewanted=all
> > 
> > Scientists Begin to Grasp the Stealthy Spread of
> > Cancer 
> > 
> > By LAURIE TARKAN
> > Published: August 15, 2006
> > 
> > . . .
> > Researchers are looking at a number of events that
> > occur in the microenvironment that give a cancer
> > cell
> > a leg up as soon as it arrives. These changes
> > involve
> > both normal cells that reside in that tissue and
> the
> > body’s roaming immune cells. 
> > 
> > “The tumor cells co-opt these cells to act in a
> way
> > that’s conducive for the growth of the
> metastasis,”
> 
=== message truncated ===

+++++++++++++++++++
>From an article about physicians doing clinical studies: 

"It was just before an early morning meeting, and I was really trying to get to the bagels, but I couldn't help overhearing a conversation between one of my statistical colleagues and a surgeon.

Statistician: "Oh, so you have already calculated the P value?"

Surgeon: "Yes, I used multinomial logistic regression."

Statistician: "Really? How did you come up with that?"

Surgeon: "Well, I tried each analysis on the SPSS drop-down menus, and that was the one that gave the smallest P value"."

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com

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