[ RadSafe ] Fwd: FW: Positive immunological response to chronic low dose rate radiation

[howard long]

Hormesis - Homeopathy discussion in pseudoscientific magazines is quite lacking in the objectivity for publishing shown in this.
   
  Howard Long 

"Yasuhiro Ina, D.M.Sc." <hyper-max at amber.plala.or.jp> wrote:
  Date: Tue, 07 Feb 2006 15:22:09 +0900
Subject: FW: Positive immunological response to chronic low dose rate
radiation
From: "Yasuhiro Ina, D.M.Sc." <hyper-max at amber.plala.or.jp>
To: <rad-sci-l at WPI.EDU>
CC: "Muckerheide, James" <jimm at WPI.EDU>,
"Prof. Dr. Ludwig E. Feinendegen" <feinendegen at gmx.net>,
"Prof. Dr. Thomas D. Luckey" <tdl108 at sunflower.com>

Dear great friends all over the world  ( CC :  Jim, Ludwig and Don),

Thank you very much for your circulating the e-mail below about our newly published paper on  " Immunological Network Activation by Chronic Low-Dose-Rate Radiation ".  I believe most important point is not "Dose" but also "Dose-Rate".  I consider the following papers of our recent work suggest it strongly.  Please send an e-mail to me if you want them for review.  I will send you the PDF files promptly. 

Ina Y and Sakai K.  Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice.  Radiation Research  2004  Feb ; 161 (2) : pp.168-173.

Ina Y, Tanooka H, Yamada T, Sakai K.  Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice.  Radiation Research  2005  Feb ; 163 (2) : pp.153-158.

Ina Y and Sakai K.  Further study of prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice: Effects of whole-life irradiation.  Radiation Research  2005  Apr ; 163 (4) : pp.418-423.

Ina Y and Sakai K.  Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: Analysis of immune cell populations and surface molecules.  International Journal of Radiation Biology  2005  Oct ; 81 (10) : pp.721-729.


I wish you very much your good health and continued success for real science. 

With very best wishes,
Yours,
Yasuhiro (Yasuhiro Ina, D.M.Sc.)


----------
From: "Muckerheide, James" <jimm at WPI.EDU>
Date: Mon, 6 Feb 2006 18:27:35 -0500
To: <rad-sci-l at WPI.EDU>
Subject: Positive immunological response to chronic low dose rate radiation

Friends, 

This paper is just pub'd by IJRB (despite the delayed date).  Note that the chronic low dose rate radiation effects is also compared with the effects of the same dose at a single acute dose (at a high dose rate). 

Let me know if you want this paper for review. 


Regards, Jim Muckerheide 

=================== 

Int. J. Radiat. Biol.  Vol.81, No.10, pp.721-729, 2005

"Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: Analysis of immune cell populations and surface molecules"
(Immunological network activation by low-dose-rate radiation)

by Yasuhiro Ina (Corresponding Author) and Kazuo Sakai

Abstract 
Purpose:  To analyse the effects of chronic whole body low-dose-rate irradiation on the immune system in various wild-type mouse strains in comparison with the effects from acute high-dose-rate irradiation. 

Materials and methods:  Wild-type mouse strains (C57BL/6, BALB/c, C3H/He, DBA/1, DBA/2 and CBA) were observed after chronic low-dose-rate gamma irradiation at 1.2 mGy/hour by intensive analysis of immune cell populations and their various surface molecules, together with antibody-producing activity both with and without immunization by sheep red blood cells (SRBC).  The cell surface functional molecules [cluster of differentiation (CD) 3, CD4, CD8, CD19, CD45R/B220, intercellular adhesion molecule (ICAM)-1, Fas, natural killer (NK)-1.1, chemokine {C-X-C motif} receptor 4 (CXCR4) and chemokine {C-C motif} receptor 5 (CCR5)] and activation molecules [thymocyte-activating molecule (THAM), CD28, CD40, CD44H, CD70, B7-1, B7-2, OX-40 antigen, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), CD30 ligand and CD40 ligand] were studied in the bone marrow, thymus, spleen, lymph nodes and peripheral blood by flow cytometry.  

Results:  By chronic low-dose-rate irradiation alone, CD4+ T cells and CD8 molecule expression increased significantly by a maximum of 30 %, while CD40+ B cells decreased significantly.  Increases of CD4+ T cells, CD40+ B cells and anti-SRBC antibody-producing cells by immunization were significantly enhanced by continuous low-dose-rate irradiation at 1.2 mGy/hour.  CD3- CD4+ T cells, representative of abnormal immune cells, were absent in the chronically low-dose-rate-irradiated mice, while a dose-dependent increase of these cells was found in acutely high-dose-rate-irradiated mice given the same total doses.  

Conclusion:  Chronic low-dose-rate radiation activated the immune system of the whole body.  

Keywords:  Chronic low-dose-rate irradiation, immunological network activation, immune cell populations, cell surface molecules, abnormal immune cells, wild-type mouse strains