[ RadSafe ] definition of Rad

[Brennan, Mike (DOH)]

There are much easier ways of killing mice. 

-----Original Message-----
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On
Behalf Of Rainer.Facius at dlr.de
Sent: Thursday, October 04, 2007 2:44 AM
To: eic at shaw.ca; radsafe at radlab.nl
Subject: AW: [ RadSafe ] definition of Rad

Kai, 
 
you may need up to thousand rads (up to 10 Gy)  of acute sparsely
ionizing radiation to kill an adult healthy mouse.
 
Rainer 
 

Morton  J I, Siegel B V, Radiation Sensitivity of New Zealand Black Mice
and the Development of Autoimmune Disease and Neoplasia. Proc Natl Acad
Sci U S A. 68#1(1971)124-126.

 
"Young New Zealand Black (NZB) mice manifested extremely high resistance
to the lethal effects of acute exposures to ionizing radiation, with a
dose necessary to kill 50% of the animals within 30 days, LD50(30), of
964 roentgens (R) at 30 days of age and of 856 R for 90-day-old mice. In
contrast, Coombs' positive 9-month-old NZB mice (with low primary immune
response) were highly susceptible (LD50(30) = 543 R), possibly because
of anemia-stimulated erythropoiesis leading to a depletion of stem
cells."
 
Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970

________________________________

Von: radsafe-bounces at radlab.nl im Auftrag von Kai Kaletsch
Gesendet: Di 02.10.2007 18:10
An: radsafe at radlab.nl
Betreff: [ RadSafe ] definition of Rad



Friends,

According to the Wikipedia entry for 'Rad', it was defined from 1918 to
1953 as the unit of X-ray dose required to kill a mouse. 1) I never
heard this definition before and 2) This seems like a very low dose for
killing anything.

This is somewhat before my time and I normally use SI units. Is the
Wikipedia statement correct?

Kai

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