[ RadSafe ] definition of Rad

Sat Oct 6 15:20:34 CDT 2007

If anyone should try to kill mice via radiation exposure, they might want to 
be sure they're not feeding, or the mice aren't getting, food high in 
Vitamin E.

Back in the 1970s, I recall seeing some abstracts of US government 
translated research concerning a Soviet experiment with mice who were 
administered high levels of Vitamin E before gamma irradiation. Those mice 
with high Vit. E levels had an LD50(30) twice as high as the unirradiated 
control group.  This is what was reported in some obscure research summary 
report.

Any more recent work on this subject that folks know about?

Stewart Farber, MS Public Health
Consulting Scientist
Farber Medical Solutions, LLC
1285 Wood Ave.
Bridgeport, CT 06604
[203] 441-8433 [office]
email: radproject at sbcglobal.net
website: http://farber-medical.com
=============================
----- Original Message ----- 
From: "Brennan, Mike (DOH)" <Mike.Brennan at DOH.WA.GOV>
To: <radsafe at radlab.nl>
Sent: Friday, October 05, 2007 7:23 PM
Subject: RE: [ RadSafe ] definition of Rad

There are much easier ways of killing mice.

-----Original Message-----
From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On
Behalf Of Rainer.Facius at dlr.de
Sent: Thursday, October 04, 2007 2:44 AM
To: eic at shaw.ca; radsafe at radlab.nl
Subject: AW: [ RadSafe ] definition of Rad

Kai,

you may need up to thousand rads (up to 10 Gy)  of acute sparsely
ionizing radiation to kill an adult healthy mouse.

Rainer

Morton  J I, Siegel B V, Radiation Sensitivity of New Zealand Black Mice
and the Development of Autoimmune Disease and Neoplasia. Proc Natl Acad
Sci U S A. 68#1(1971)124-126.

"Young New Zealand Black (NZB) mice manifested extremely high resistance
to the lethal effects of acute exposures to ionizing radiation, with a
dose necessary to kill 50% of the animals within 30 days, LD50(30), of
964 roentgens (R) at 30 days of age and of 856 R for 90-day-old mice. In
contrast, Coombs' positive 9-month-old NZB mice (with low primary immune
response) were highly susceptible (LD50(30) = 543 R), possibly because
of anemia-stimulated erythropoiesis leading to a depletion of stem
cells."

Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970

________________________________

Von: radsafe-bounces at radlab.nl im Auftrag von Kai Kaletsch
Gesendet: Di 02.10.2007 18:10
An: radsafe at radlab.nl
Betreff: [ RadSafe ] definition of Rad

Friends,

According to the Wikipedia entry for 'Rad', it was defined from 1918 to
1953 as the unit of X-ray dose required to kill a mouse. 1) I never
heard this definition before and 2) This seems like a very low dose for
killing anything.

This is somewhat before my time and I normally use SI units. Is the
Wikipedia statement correct?

Kai

_______________________________________________
You are currently subscribed to the RadSafe mailing list

Before posting a message to RadSafe be sure to have read and understood
the RadSafe rules. These can be found at:
http://radlab.nl/radsafe/radsaferules.html

For information on how to subscribe or unsubscribe and other settings
visit: http://radlab.nl/radsafe/

_______________________________________________
You are currently subscribed to the RadSafe mailing list

Before posting a message to RadSafe be sure to have read and understood
the RadSafe rules. These can be found at:
http://radlab.nl/radsafe/radsaferules.html

For information on how to subscribe or unsubscribe and other settings
visit: http://radlab.nl/radsafe/
_______________________________________________
You are currently subscribed to the RadSafe mailing list

Before posting a message to RadSafe be sure to have read and understood the 
RadSafe rules. These can be found at: 
http://radlab.nl/radsafe/radsaferules.html

For information on how to subscribe or unsubscribe and other settings visit: 
http://radlab.nl/radsafe/