[ RadSafe ] Chris Busby - troll? NO!; final statement on this issue; infant leukemia

Tue Apr 26 08:12:47 CDT 2011

Did you miss Steven Dapra's post? His well cited post did not look irritated at all and was very civil. It utilized many of your own citations to show that your conclusions were overstated based upon the work of those authors. 

I have been awaiting your response to his critique. It appears to be scientifically strong and is currently unaddressed by yourself. 

Feel free to take a couple of days to read it over. 

Sent from my iPad

On Apr 26, 2011, at 2:50 AM, Busby Chris <C.Busby at ulster.ac.uk> wrote:

> Gentlemen,
> I can see you are becoming irritated by all this, and I have learned all I need to learn about what you think and how you think it. It was not my intention to engage in exchanges of insults, though I have received quite a lot of insults I have tried to remain civil and keep this on a level of discourse. Only one of you has engaged with the Chernobyl infants leukemia proofs and his idea was that the parents ate more vegetables only at the time of the fallout. I have given you all ample time to discuss this issue of the increased levels of infant leukemia which do falsify your risk model since the doses inthe 5 countries where this was reported (in the papers I uploaded and cited for you)were well below background.  No one has addressed this, all that has happened has been attacks on me and references to other things that are not relevant.
> If no one replies in one more week on the infant leukemia issue I will say no more.
> It has been intersting.
> Sincerely
> Chris
> 
> Paris
> 
> ---; --Original Message-----
> From: radsafe-bounces at agni.phys.iit.edu on behalf of Busby Chris
> Sent: Tue 26/04/2011 08:33
> To: The International Radiation Protection (Health Physics) Mailing List; The International Radiation Protection (Health Physics) Mailing    List
> Subject: Re: [ RadSafe ] Chris Busby - troll? NO!
> 
> There are significant radiation related repair mechanisms. I agree. I do not think LNT is correct. In that I agree with the hormesis people. But.
> Chris
> 
> 
> -----Original Message-----
> From: radsafe-bounces at agni.phys.iit.edu on behalf of Larry Addis
> Sent: Tue 26/04/2011 03:24
> To: 'The International Radiation Protection (Health Physics) Mailing    List'
> Subject: Re: [ RadSafe ] Chris Busby - troll? NO!
> 
> That's very interesting Dan. 
> 
> Thanks,
> 
> Larry Addis
> 
> -----Original Message-----
> From: radsafe-bounces at health.phys.iit.edu
> [mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Dan W McCarn
> Sent: Monday, April 25, 2011 7:25 PM
> To: 'The International Radiation Protection (Health Physics) MailingList'
> Subject: Re: [ RadSafe ] Chris Busby - troll? NO!
> 
> Hi Mike -
> 
> One of the most interesting papers that I have read (now several years old)
> was a reporting of research from M.D. Anderson & Duke University focused on
> the study of radiation effects on glioblastoma, a form of brain cancer that
> is radioresistant. 
> 
> Shideng Bao1, Qiulian Wu1, Roger E. McLendon, Yueling Hao1, Qing Shi1, Anita
> B. Hjelmeland, Mark W. Dewhirst, Darell D. Bigner & Jeremy N. Rich, 2006,
> Glioma stem cells promote radioresistance by preferential activation of the
> DNA damage response, doi:10.1038/nature05236, Published online 18 October
> 2006.
> 
> Quote
> ABSTRACT
> Ionizing radiation represents the most effective therapy for glioblastoma
> (World Health Organization grade IV glioma), one of the most lethal human
> malignancies1, but radiotherapy remains only palliative2 because of
> radioresistance. The mechanisms underlying tumour radioresistance have
> remained elusive. Here we show that cancer stem cells contribute to glioma
> radioresistance through preferential activation of the DNA damage checkpoint
> response and an increase in DNA repair capacity. The fraction of tumour
> cells expressing CD133 (Prominin-1), a marker for both neural stem cells and
> brain cancer stem cells3-6, is enriched after radiation in gliomas. In both
> cell culture and the brains of immunocompromised mice, CD133-expressing
> glioma cells survive ionizing radiation in increased proportions relative to
> most tumour cells, which lack CD133. CD133-expressing tumour cells isolated
> from both human glioma xenografts and primary patient glioblastoma specimens
> preferentially activate the DNA damage checkpoint in response to radiation,
> and repair radiation-induced DNA damage more effectively than CD133-negative
> tumour cells. In addition, the radioresistance of CD133-positive glioma stem
> cells can be reversed with a specific inhibitor of the Chk1 and Chk2
> checkpoint kinases. Our results suggest that CD133-positive tumour cells
> represent the cellular population that confers glioma radioresistance and
> could be the source of tumour recurrence after radiation. Targeting DNA
> damage checkpoint response in cancer stem cells may overcome this
> radioresistance and provide a therapeutic model for malignant brain cancers.
> 
> End Quote
> 
> Chk1 and Chk2 checkpoint kinases were used in clinical trials in
> glioblastoma patients demonstrating the presence of CD133 to reduce
> radioresistance by blocking DNA checkpoint response.  These clinical trials
> happened to include my old officemate at Shell Oil, Uncle Bernie Goldberg,
> who died at the age of 86. 
> 
> The fact that this mechanism is important for glioblastoma suggests to me
> that radioresistance is a normal part of the makeup of DNA, and likely has
> been since early in Earth's history when background radiation levels were
> significantly higher.
> 
> Dan ii
> 
> --
> Dan W McCarn, Geologist
> 108 Sherwood Blvd
> Los Alamos, NM 87544-3425
> +1-505-672-2014 (Home - New Mexico)
> +1-505-670-8123 (Mobile - New Mexico)
> HotGreenChile at gmail.com (Private email) HotGreenChile at gmail dot com
> 
> 
> -----Original Message-----
> From: radsafe-bounces at health.phys.iit.edu
> [mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Stabin, Michael
> Sent: Monday, April 25, 2011 11:35
> To: radsafe at agni.phys.iit.edu
> Subject: Re: [ RadSafe ] Chris Busby - troll? NO!
> 
> 
> I agree with Franz really that this was not a completely accurate term to
> use. It is not like the idiots (mostly bored adolescent boys I think) who
> pop up on serious lists and chat rooms cursing and saying idiotic things
> just to annoy people. I was being a bit provocative in the use of this term.
> I am with Jerry Cohen on this, after the comment about "millions of people
> dying" from low level radiation exposures and "how can you all live with
> yourselves?", I saw that this is not a serious discussion and I'm not going
> to pay any further attention to it or to him. Those of you who wish to
> continue engaging this "stuff" (another polite term), feel free. Even if I
> were still the list moderator, I would see no reason to stop debate like
> this, it has seemed mostly civil to me. But it is quite a pointless waste of
> time, methinks.
> 
> 
> Mike
> 
> Michael G. Stabin, PhD, CHP
> Associate Professor of Radiology and Radiological Sciences
> Department of Radiology and Radiological Sciences
> Vanderbilt University
> 1161 21st Avenue South
> Nashville, TN 37232-2675
> Phone (615) 343-4628
> Fax   (615) 322-3764
> e-mail     michael.g.stabin at vanderbilt.edu
> internet   www.doseinfo-radar.com
> 
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