[ RadSafe ] Ra-223 Chloride - FDA Approval

[Jan John]

For medical purposes, you get Ra-223 as a daughter of Th-227 that is obtained by irradiating Ra-226 by neutrons and successive beta decays of the resulting Ra-227 to Ac-227 and Th-227.
See also http://www.algeta.com/ 
J. John

-----Original Message-----
From: radsafe-bounces at health.phys.iit.edu [mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Cary Renquist
Sent: Thursday, May 16, 2013 12:42 AM
To: The International Radiation Protection (Health Physics) MailingList
Subject: Re: [ RadSafe ] Ra-223 Chloride - FDA Approval

Ra-223 is progeny in the U-235 decay chain...

FYI: for production mode, one of easiest sources is the LUND/LBNL Table of Isotopes:
http://j.mp/15O1t21
e.g. For Ra-223, Prod. mode:  Naturally occurring

However, that TOI doesn't list potential "parent" nuclides...
For following decay chains, the Korea Atomic Energy Research Institute TOI is the easiest to use...
http://j.mp/YWXP2V
 

---
Cary Renquist
cary.renquist at ezag.com


-----Original Message-----
From: radsafe-bounces at health.phys.iit.edu
[mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Brennan, Mike
(DOH)
Sent: Wednesday, 15 May 2013 2:31 PM
To: The International Radiation Protection (Health Physics) MailingList
Subject: Re: [ RadSafe ] Ra-223 Chloride - FDA Approval

"The U.S. Food and Drug Administration today approved Xofigo (radium Ra
223 dichloride) to treat men with symptomatic late-stage (metastatic) castration-resistant prostate cancer that has spread to bones but not to other organs. It is intended for men whose cancer has spread after receiving medical or surgical therapy to lower testosterone."

Note to self: don't get "castration-resistant prostate cancer".

How do you get Ra 223?  No path leaps out when I look at the chart of the nuclides. 

-----Original Message-----
From: radsafe-bounces at health.phys.iit.edu
[mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Chris Alston
Sent: Wednesday, May 15, 2013 2:03 PM
To: The International Radiation Protection (Health Physics) Mailing List
Subject: [ RadSafe ] Ra-223 Chloride - FDA Approval

Radsafers

Please see:

http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm352363.htm

It is hard to tell from the notice.  But I thought that this drug (did they change the name from Alpharadin, or is that a competitor still in
IND?) was  in trials for the relief of pain from metastases to bone, and that, incidentally, the investigators showed that pts had extensions of life (I hope, sincerely, of decent quality, relatively speaking).  Is it approved for the latter use, or is the FDA just saying that was why they fast-tracked it?

Cheers
cja
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