[ RadSafe ] Cancer (Chemical, Physical Basis)
JPreisig at aol.com
JPreisig at aol.com
Sun Nov 9 22:13:21 CST 2014
Hope you are well.
Guess there is another level of complexity introduced to the model of
a normal human cell --- the existence of the cellular nucleus. The
nucleus is the central part of a cell, membrane enclosed and an organelle. Been
so long since I even learned of organelles. The DNA is enclosed in the
I'll revisit somewhat what I think I am modeling in a cellular cancer
genesis model. We start with a normal cell exposed internally or
externally to radiation or perhaps to a fluid containing some percentage of
chemical(s) outside of the cell.
1. When exposed to a chemical carcinogen the cell wall/boundary may
expand so that the cell might obtain more nutrients and/or oxygen from the
volume exterior to the cell.
2. The cell itself may try to accelerate osmosis/diffusion, other
processes to obtain more nutrients if surrounded by a matrix of a chemical
carcinogen etc. This may not be a good thing, if a
carcinogen/mutagen/chemical is being brought into the cell.
3. If a cell is immersed in a carcinogen/mutagen/chemical it may try
to reproduce quickly to obtain more oxygen/nutrients. Again this could
provide some difficulty/exposure if the cell is incorporating
carcinogens/chemicals etc. into its immediate volume.
4. (NEW???) The cell nucleus boundary is another interface which
carcinogens/chemicals etc. must cross to get to the interior of the nucleus.
This interface crossing may be done by diffusion, osmosis, other processes.
Once the nucleus boundary is crossed (this process should be modeled by
scientists etc.) carcinogen/chemical exposure can happen to the DNA and
other substances within the cellular nucleus. At this point chemical
reactions, which are dependent on the chemicals involved, can occur and can modify
the DNA, and thereby modify the various bodily traits contained in the DNA.
What goes on is strongly dependent on which chemicals are involved. One
wonders at this point if the DNA has any information on how to respond to
such chemical/carcinogen invasion, possibly dependent on which chemicals are
I will leave this research topic to those folks who are working on human
DNA mapping. Depending on which parts of the DNA are affected, various body
organs etc. can be affected. If the chemical concentation is sufficient
(remember the concept of titer/titre from you Radiation Chemistry class???),
and perhaps if the body's immune system is weak enough (without yet
modeling the body's adaptive pocesses, Mohan Doss), the chemically-induced
DNA-modification processes can go forward, affecting DNA functions, cellular
division and so on. No wonder there are so many different bodily cancers. So,
maybe all the preceding statements describe somewhat how a normal human
cell is turned into a cancerous cell. Possibly benign cells becoming
With the many new supercomputers, perhaps these various processes can
be mathematically modeled, or perhaps tested in the laboratory. The
diffusion/osmosis rate across the cell boundary may be different from the rate
across the cell nucleus boundary. Perhaps the body does have various
defense systems (the basis for immunotherapy???) against cancer induction and
Of course, more physical cancer induction may involve radiation
(alpha, beta, gamma, xray, heavy ions)
hitting cells from internal or external sources. From Eric Hall's book on
Radiation Biology/Biophysics or other books you all??? may be familiar
with the various processes associated with radiation-produced cancer induction
--- single strand DNA breaks, double strand breaks, knock-out collisions,
various scattering processes, etc. Some mutations will go forward and
produce various deleterious (or perhaps even positive) effects. There are
people on Radsafe who are much more qualified to speak on these processes than
But for one thing, compare the size of the various radiations versus the
size/scale of a DNA strand. I wish good luck, and fast/efficient computing
facilities to anyone trying to model all these various processes, especially
Regards, Joe Preisig
More information about the RadSafe