[ RadSafe ] Interesting study with a potential radiation mitigating drug

[Ed Waller]

I started a talk once on medical decorporation with an introductory slide:

"If we have to decorporate radionuclides from mice, rats or beagles, we have
it made!"

These studies are important first steps to better medical countermeasures.
One of my worries is that individual variability in humans might negate
positive outcomes observed in animal models. In any case, still worth
studying.

Ed

-----Original Message-----
From: radsafe-bounces at health.phys.iit.edu
[mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Colette Tremblay
Sent: Friday, January 23, 2015 3:44 PM
To: The International Radiation Protection (Health Physics) Mailing List
Subject: Re: [ RadSafe ] Interesting study with a potential radiation
mitigating drug

Hi Joe,

The investigators used a chemical named DBIBB to mitigates in mice the
injuries caused by high-dose ionizing radiation. 

The substance, when administered up to 72 hours postirradiation, reduced
mortality in mice. DBIBB mitigated the gastrointestinal radiation syndrome,
reduced programmed cell death and enhanced DNA repair in the animals. DBIBB
also increased the survival of mice suffering from the hematopoietic acute
radiation syndrome after total-body irradiation. 

The endpoint of the study was mortality at day 30 following a 15 Gy whole
body dose. In the control  group, only one mouse out of 14 per group
survived to day 30 (93% lethality), and the mean survival time was 8 days.
In a group receiving low dose DBIBB (1 mg/kg, 26 hour after irradiation), 2
mice were alive at day 30 and the mean survival time was 15 days. In the
high dose group (10 mg/kg), 10 out of 14 mice were alive on day 30. It opens
up the possibility of future treatments that could administered hours, even
days, after irradiation.

Colette

-----Message d'origine-----
De : radsafe-bounces at health.phys.iit.edu
[mailto:radsafe-bounces at health.phys.iit.edu] De la part de JPreisig at aol.com
Envoyé : 22 janvier 2015 16:29 À : radsafe at health.phys.iit.edu Objet : Re: [
RadSafe ] Interesting study with a potential radiation mitigating drug

Colette,
 
     What does all that mean???
 
     Joe Preisig
 
 
 
 
In a message dated 1/22/2015 3:44:42 P.M. Eastern Standard Time,
Colette.Tremblay at ssp.ulaval.ca writes:

The  citation is :

Patil et al., Combined Mitigation of the Gastrointestinal  and Hematopoietic
Acute Radiation Syndromes by an LPA2 Receptor-Specific  Nonlipid Agonist,
Chemistry & Biology (2015),
http://dx.doi.org/10.1016/j.chembiol.2014.12.009

The complete paper is  available free of charge (see link at the end of the
 citation)

Colette

[cid:image001.gif at 01D0365A.37F58C20]

[cid:image002.gif at 01D0365A.37F58C20]

[cid:image004.gif at 01D0365A.37F58C20]<http://www.ulaval.ca/>




Colette  Tremblay
Spécialiste en radioprotection
Service de sécurité et de  prévention
Pavillon Ernest-Lemieux, local 1533
Poste   2893

Avis de
confidentialité<http://www.rec.ulaval.ca/lce/securite/confidentialite.htm>


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