Re: Info on animal experiment at Los Alamos

[Muckerheide <muckerheide@mediaone.net>]

Hi Mike,

Interesting. Didn't come up on my LANL report search!? However, from
this abstract, this sounds like the early phase of the 1982 LANL
report on this experiment: Spalding, Thomas, and Tietjen (a 1.8MB .pdf
file) that I had sent to Philippe before (and sent the url to radsafe
before). 

I strongly recommend that anyone interested in the dose/dose-rate
radiation health effects review it. (Except for the pages of "ascii
plot" at the back, it is a brief and descriptive report - a dozen
pages+ ? - it's been a while. :-)

By the way, "Thomas" is Bob Thomas, HPS Fellow, and all-round great
guy! :-)
I sent Jake Spalding's number to Philippe. Bob is on email if anyone's interested.

Regards, Jim
muckerheide@mediaone.net
========================

"Michael C. Baker" wrote:
> 
> A search of the LANL unclassified report database came up with the
> following document:
> 
> Title:  Late biological effects of ionizing radiation as influenced by
> dose, dose rate, age at exposure, and genetic sensitivity to neoplastic
> transformation
> 
> Authors: Spalding, J.F.; Tietjen, G.L.; Prine, J.R.
> Year: 1978
> Report Number:  LA-UR-78-681; IAEA-SM-224/201; CONF-780306-4
> Doc. Type:  Report
> Description: 11 p.
> Conference:  Symposium on late biological effects of ionizing radiation (13
> Mar 1978 : Vienna, Austria)
> 
> Abstract:
> 
> A most comprehensive investigation is in progress at the Los Alamos
> Scientific Laboratory to study the late biological effects of whole-body
> exposure to gamma irradiation as they may be influenced by total dose, dose
> rate, age at exposure, and genetic background. Strain C57B1/6J mice of four
> age groups (newborn, 2, 6, and 15 months) were given five doses (20, 60,
> 180, 540, and 1620 rad) of gamma rays, with each dose being delivered at
> six dose rates (0.7, 2.1, 6.3, 18.9, 56.7 rad/day and 25 rad/min). Forty to
> sixty mice were used in each of the approximately 110 dose/dose-rate and
> age combinations. The study was done in two replications with an equal
> number of mice per replication. Strain RF/J mice were used in a companion
> study to investigate the influence of genetic background on the type and
> magnitude of effect. Results of the first and second replications of the
> 15-month-old age group and data on the influence of genetic background on
> biological response have been completed, and the  results show no
> significant life shortening within the dose and dose-rate range used.
> 
> I think this is the document you already have.  The database record lists
> the following email address for the authors:  gtietjen@lanl.gov
> 
> I hope this helps,
> Mike
> 
> __________________________________
> 
> Michael C. Baker
> Environmental Technology Group (E-ET)
> Los Alamos National Laboratory
> Mail Stop J594, Los Alamos, NM 87545
> 
> mcbaker@lanl.gov
> 
> (505) 667-7334 (phone)
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