Re: Info on animal experiment at Los Alamos

["Michael C. Baker" <mcbaker@lanl.gov>]

A search of the LANL unclassified report database came up with the 
following document:

Title:  Late biological effects of ionizing radiation as influenced by 
dose, dose rate, age at exposure, and genetic sensitivity to neoplastic 
transformation

Authors: Spalding, J.F.; Tietjen, G.L.; Prine, J.R.
Year: 1978
Report Number:  LA-UR-78-681; IAEA-SM-224/201; CONF-780306-4
Doc. Type:  Report
Description: 11 p.
Conference:  Symposium on late biological effects of ionizing radiation (13 
Mar 1978 : Vienna, Austria)

Abstract:

A most comprehensive investigation is in progress at the Los Alamos 
Scientific Laboratory to study the late biological effects of whole-body 
exposure to gamma irradiation as they may be influenced by total dose, dose 
rate, age at exposure, and genetic background. Strain C57B1/6J mice of four 
age groups (newborn, 2, 6, and 15 months) were given five doses (20, 60, 
180, 540, and 1620 rad) of gamma rays, with each dose being delivered at 
six dose rates (0.7, 2.1, 6.3, 18.9, 56.7 rad/day and 25 rad/min). Forty to 
sixty mice were used in each of the approximately 110 dose/dose-rate and 
age combinations. The study was done in two replications with an equal 
number of mice per replication. Strain RF/J mice were used in a companion 
study to investigate the influence of genetic background on the type and 
magnitude of effect. Results of the first and second replications of the 
15-month-old age group and data on the influence of genetic background on 
biological response have been completed, and the  results show no 
significant life shortening within the dose and dose-rate range used.


I think this is the document you already have.  The database record lists 
the following email address for the authors:  gtietjen@lanl.gov

I hope this helps,
Mike

__________________________________

Michael C. Baker
Environmental Technology Group (E-ET)
Los Alamos National Laboratory
Mail Stop J594, Los Alamos, NM 87545

mcbaker@lanl.gov

(505) 667-7334 (phone)
(505) 665-8346 (fax)
(505) 996-3519 (pager)
__________________________________

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