RE: Sm153 & radionuclidic impurities in radiopharmaceuticals

["Moroney, Roger W" <Roger.Moroney@mkg.com>]

We were doing some work with Sm-153 here. I did some assays to determine the
Eu-154 contaminate levels. The sample was counted on a HPGe system. Here is
what I found:

Sm-153 activity was 0.505 uCi in 5 cc on 3/17/98. The sample was counted on
4/10/98 for two hours. The Eu-154 concentration was 1.274E-5 uCi/cc, Eu-152
was < MDA (9.5E-6 uCi/cc). MDA's for other isotopes ranged from 10E-6 to
10E-7 uCi/cc except at lower energies which were ~10E-5. Normal activity at
time of ship is 204 mCi of Sm-153.

We had a concern here for a buildup of long-lived by-product material and
disposal costs. I understand that this problem also killed some very
promising applications in bone cancer therapy.


There are standards for radionuclidic purity set by the US FDA. We have a
very large Quality Control group who are responsible for ensuring compliance
with all domestic and foreign drug regulations. I don't know the limits
off-hand but I do know we have rejected Tl-201 raw material from outside
vendors due to high Tl-202 levels.

Roger Moroney
Health Physicist
Mallinckrodt, Inc.
314.654.7457 voice
314.654.7571 fax
roger.moroney@mkg.com


-----Original Message-----
From: Carolan, Martin [mailto:CarolanM@iahs.nsw.gov.au]
Sent: Thursday, January 20, 2000 7:38 PM
To: Multiple recipients of list
Subject: RE: Sm153



I have just collected a multipeak spectrum from a fraction of a Sm153 dose
which was delivered about 6 months ago for a patient who cancelled. (NB from
an Autralian supplier of Sm153.) I have not yet correlated the observed
peaks with Eu 154 but the dose rate on the exterior of the vial is about the
order of 30uSv/hr - six months after the 6 GBq of Sm153 was delivered. 

Regards

Martin Carolan
Senior Physicist
Department of Nuclear Medicine
Wollongong Hospital
Wollongong NSW 2500
AUSTRALIA
email carolanm@iahs.nsw.gov.au <mailto:carolanm@iahs.nsw.gov.au> 
phone 61 2 4222 5224
fax 61 2 4222 5238
internal page # 252.
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