Re: Contributions to the historical record

["Bjorn Cedervall" <bcradsafers@hotmail.com>]

>biological responses can only potentially be beneficial, including 
>consistency with the role of stimulating immune responses that are being 
>applied in various modalities to successfully treat cancer.

I have some difficulty accepting the positive effect as it is known that 
point mutations just accumulate as we get older. I wouldn't want to speed up 
that process (with priming doses) which means that my genome is destroyed at 
a faster pace. Also, a priming dose (chemical or physical) for instance must 
be put into perspective: What are the levels? Say that some protective 
aspect is found - do we then need a priming doses every third day or so? The 
probability for say a dangerous translocation (such as a promotor of an 
active gene being moved to the promotor region of a cell proliferation gene 
that should be shut down) to occur must reasonably increase in relation to 
dose.

Point mutations can be beneficial for a population (for adaption & 
evolution) but for the individual I would still put a question mark because 
of the sequence DSB->chromosomal aberration->mutation/cancer/cell death (OK, 
I know about apoptosis).

Just my own thoughts,

Bjorn Cedervall   bcradsafers@hotmail.com

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