ABSTRACT Shen et al. 1991 - TBI cure of Friend virus in mice

[Jim Muckerheide <jmuckerheide@delphi.com>]

Friends, ["Radiation science group", plus "ANS/industry group"]

Yet another of the "large body of credible, replicable, and statistically
significant data indicating that there is no harm, and indicating that there
ARE health benefits from low-level radiation exposure."

Please review the abstract below. It confirms again that low-dose irradiation
(LDI) stimulates the immune system to successfully treat ("cure")
virus-infected mice.

Note: The conclusion "...the cure [Note "THE CURE"] of FVC-P-infected mice by
low-dose TBI may [Note: "MAY"] result from activation of the IFN-gamma system
and IL-2 production."  The issue is not the "cure by TBI," just the specific
mechanisms stimulated by TBI to effect that cure.

Please comment/review, and send the paper (electronic?) if possible. 

Inquire to check on whether we've gotten it. Your review is invited anyway.

In case you want to see the 'original' abstract:
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1908321&dopt=Abstract

Thanks.

Regards, Jim
============
muckerheide@mediaone.net
Radiation, Science, and Health
Box 843, Needham, MA 02494
Center for Nuclear Technology and Society at WPI
RSH 781-449-2214  fax 781-449-6464
(day) 508-820-2039 fax 508-820-2094 or -2049
(home) 781-444-8319 
============================================

Lymphokine Cytokine Res 1991 Apr;10(1-2):105-9

 Cure with low-dose total-body irradiation of the hematological disorder
induced in mice with the Friend virus: possible mechanism involving
interferon-gamma and interleukin-2. 

 Shen RN, Lu L, Feng GS, Miller J, Taylor MW, Broxmeyer HE 

 Department of Medicine (Hematology/Oncology), Indiana University School of
Medicine, Indianapolis 46202.

 The effects of split low-dose total-body irradiation (TBI; 150 cGy) on
production of interferon (IFN)-gamma and Interleukin-2 (IL-2) and on the
growth characteristics of erythroid progenitor cells (BFU-E) have been
assessed in normal mice, normal mice receiving TBI only, mice infected with
the polycythemia-inducing strain of the Friend virus complex (FVC-P), and
FVC-P infected mice receiving 150 cGy TBI on days 5 and 12. It was found that
lymphocytes from the spleens of TBI-treated mice previously infected with
FVC-P produced in response to phytohemagglutinin (PHA) and concanavalin A (Con
A) stimulation up to 15 times greater amounts of IFN-gamma than cells from
untreated FVC-P-infected mice. IL-2 production in Con A-stimulated spleen cell
cultures also increased when cells were isolated from FVC-P-infected mice
treated by low-dose TBI compared to untreated FVC-P-infected mice. TBI
treatment was associated with greater than 99% ablation of
"erythropoietin-independent" BFU-E colony formation. The results suggest that
the cure of FVC-P-infected mice by low-dose TBI may result from activation of
the IFN-gamma system and IL-2 production.
************************************************************************
The RADSAFE Frequently Asked Questions list, archives and subscription
information can be accessed at http://www.ehs.uiuc.edu/~rad/radsafe.html