RE: dissolved gases and their effects on DNA damage

["Wright, Will (DHS-PSB)" <WWright2@dhs.ca.gov>]

One of the most effective mechanism of any molecular effect is most
effectively demonstrated in the ability of a molecule to be exist as a free
radical.  Radiogenic damage can be indirect as well with the production of H
and O by hydrolysis of H2O. both H and O are quite reactive as well as
products OH, HO2, H2O2.  Is suppose the hydyolysis of H2S would also produce
similarly characterized products.  Not so sure of N2 but other forms as the
oxides are quite reactive.

		-----Original Message-----
		From:	ruth_weiner [mailto:ruth_weiner@email.msn.com]
		Sent:	Thursday, August 03, 2000 8:39 AM
		To:	Multiple recipients of list
		Subject:	Re: dissolved gases and their effects on DNA
damage

		Molecular oxygen has a peculiar structure -- a sort of
"three-electron"
		bond, and is paramagnetic (you know those clips they clip on
your finger to
		measure the oxygen content of your blood?  they work on the
basis of the
		paramagnetic absorption of oxygen).  I suspect that it is
this property that
		modifies radiogenic damage, so NO might do the same thing;
the electronic
		structure is not the same, but similar.  But this may be
because, to a
		chemist, everything looks like a chemical structure problem.

		Ruth Weiner
		ruth_weiner@msn.com
		-----Original Message-----
		From: Karam, Andrew <Andrew_Karam@URMC.Rochester.edu>
		To: Multiple recipients of list
<radsafe@romulus.ehs.uiuc.edu>
		Date: Thursday, August 03, 2000 8:27 AM
		Subject: dissolved gases and their effects on DNA damage


		>I have been doing some reading on the effects of oxygen in
modifying
		>radiogenic damage to DNA.  This has led me to wonder if
anyone knows of any
		>other gases that have been noted to modify DNA damage rates
(either enhance
		>OR reduce radiogenic damage).  I would imagine, for
example, that dissolved
		>hydrogen might serve to reduce damage because its presence
might help
		>scavenge free oxygen.  But I haven't a clue as to whether
or not, day,
		>dissolved CO2, N2, sulfur compounds, methane, etc. might do
anything.
		>
		>I'd appreciate any comments, speculation, or suggested
reading on this
		>matter.   Thanks!
		>
		>Andy
		>
		>Andrew Karam, CHP              (716) 275-1473 (voice)
		>Radiation Safety Officer          (716) 275-3781 (office)
		>University of Rochester           (716) 256-0365 (fax)
		>601 Elmwood Ave. Box HPH   Rochester, NY  14642
		>
		>Andrew_Karam@URMC.Rochester.edu
		>http://Intranet.urmc.rochester.edu/RadiationSafety
		>
		>If a man never contradicts himself, the reason must be that
he virtually
		>never says anything at all.  (Miguel de Unamuno, quoted in
"What is Life?"
		>by Erwin Schrodinger)
		>
	
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