Re: Hormesis?

["Harry Hinks" <harryhinks@hotmail.com>]

Mr. Muckerheide,

Why bother?

I am just trying to figure out what you are saying in comparison to articles 
like this.


Environ Health Perspect 2001 Jan;109(1):41-45 Books

Risk of Cancer in an Occupationally Exposed Cohort with Increased Level of 
Chromosomal Aberrations.

Smerhovsky Z, Landa K, Rossner P, Brabec M, Zudova Z, Hola N, Pokorna Z, 
Mareckova J, Hurychova D

The National Institute of Public Health, Prague, Czech Republic.

We used cytogenetic analysis to carry out a cohort study in which the major 
objective was to test the association between frequency of chromosomal 
aberrations and subsequent risk of cancer. In spite of the extensive use of 
the cytogenetic analysis of human peripheral blood lymphocytes in 
biomonitoring of exposure to various mutagens and carcinogens on an ecologic 
level, the long-term effects of an increased frequency of chromosomal 
aberrations in individuals are still uncertain. Few epidemiologic studies 
have addressed this issue, and a moderate risk of cancer in individuals with 
an elevated frequency of chromosomal aberrations has been observed. In the 
present study, we analyzed data on 8,962 cytogenetic tests and 3,973 
subjects. We found a significant and strong association between the 
frequency of chromosomal aberrations and cancer incidence in a group of 
miners exposed to radon, where a 1% increase in frequency of chromosomal 
aberrations was followed by a 64% increase in risk of cancer (p < 0.000). In 
contrast, the collected data are inadequate for a critical evaluation of the 
association with exposure to other chemicals.





>From: Muckerheide <muckerheide@mediaone.net>
>Reply-To: radsafe@romulus.ehs.uiuc.edu
>To: Multiple recipients of list <radsafe@romulus.ehs.uiuc.edu>
>Subject: Re: Hormesis?
>Date: Thu, 15 Feb 2001 20:50:41 -0600 (CST)
>
>Why bother.  You didn't read the last refs you requested.  And Bernie made
>clear that's not what he's saying.  (And why do you assume alpha rad to the
>lung is the important parameter?)
>
>Anyway, for a general perspective, see the following paper by Tony Brooks
>and Marv Frazier, denizens of the establishment which will be more to your
>liking :-)
>http://cnts.wpi.edu/rsh/Data_Docs/1-2/6/3/Rev%202%201263br&fr93.html
>
>Regards, Jim
>muckerheide@mediaone.net
>==========================
>
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