New paper re biological response to IR

[Muckerheide <muckerheide@MEDIAONE.NET>]

Title: New paper re biological response to IR

Friends,


Note the current summary of cellular responses to radiation from the following partial abstract. 


Regards, Jim Muckerheide

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Semin Radiat Oncol 2001 Oct;11(4):352-72

When X-ray-inducible proteins meet DNA double strand break repair.

Leskov KS, Criswell T, Antonio S, Li J, Yang CR, Kinsella TJ, Boothman DA.

Department of Human Oncology, University of Wisconsin-Madison, Madison, WI 53792, USA.

Cellular responses to ionizing radiation (IR) include:

(a) activation of signal transduction enzymes;

(b) stimulation of DNA repair, most notably DNA double strand break (DSB) repair by homologous or nonhomologous recombinatorial pathways;

(c) activation of transcription factors and subsequent IR-inducible transcript and protein changes;

(d) cell cycle checkpoint delays in G(1), S, and G(2) required for repair or for programmed cell death of severely damaged cells;

(e) activation of zymogens needed for programmed cell death (although IR is a poor inducer of such responses in epithelial cells); and

(f) stimulation of IR-inducible proteins that may mediate bystander effects influencing signal transduction, DNA repair, angiogenesis, the immune response, late responses to IR, and possibly adaptive survival responses.

The overall response to IR depends on the cell's inherent genetic background, as well as its ability to biochemically and genetically respond to IR-induced damage.

To improve the anti-tumor efficacy of IR, our knowledge of these pleiotropic responses must improve. ...