Re: New analytical approach to low dose effects

[Muckerheide <muckerheide@MEDIAONE.NET>]

> Jim,

> Can you explain "cascade-stochastic" in 25 words or less?

> 

> -- John 

> John Jacobus, MS

> Certified Health Physicist

> 3050 Traymore Lane

> Bowie, MD  20715-2024



Anything to help John,



>From the naive cascade model of multiple charged particles production, e.g.,

inelastic hadron-hadron collisions at high energies, a stochastic analysis

was developed known as the Saleh-Teich cascade-stochastic formalism. It's

been applied with the quark-gluon strings model.



Rusov has applied it to effects in track biodetectors, and extended it to

analysis in the low-dose range. It's not at all clear that it is applicable

to the actual non-linear low-dose effects found in biology. We have asked

some of the knowledgeable scientists to evaluate it.



A further treatment of the subject from a conference is provided below.



Regards, Jim

===========



Title:    Theory and Experimental Observation of Neymanís Statistics

Violation and Nonlinear Dependence ´Dose-Effectª in Track Biodetectors in

Area of Low Doses

Author(s):    Vitaly D. Rusov, Tatyana N. Zelentsova, M.M. Ovsyanko, I.S.

Melenchuk

Address:    Odessa Polytechnic University, 65044 Odessa

Country:    Ukraine

 

Based on the developed biophysical model of radiation effects the new

cascade-stochastic approach for a solution of direct and inverse tasks of

statistics of radiation-induced effects in track biodetectors is offered.

This approach contains all possibilities as for identification and

quantitative analysis of ionizing radiation (biospectrometry) and for study

of a stochastics of energy transfer in living cells (microdosimetry).



The obtained results show that the statistics of radiation-induced effects

in cells within the framework of the considered experiments is well

described by doubly stochastic Poisson processes, controlled by an

exponential response function h(x). It is confirmed by the comparative

analysis of the theoretical and experimental distributions of the

micro-nuclei on human lymphocytes cells irradiated by X-radiation in the

area of low dozes (0.1 - 1.0 Gy).



The analysis of experimental data has allowed to establish a nonlinear

character of ´dose - effectª dependence in the area of low dozes, and to

detect essential increase (in 1.3 times) of sizes of biodetector sensitive

volume (nuclear chromatin) at dozes over 0.4 Gy.



Based on thermodynamic theory of biological phase transition induced by low

dozes the quantitative and qualitative explanation of the physical mechanism

of a nonlinear response human lymphocytes of a type ´dose - effectª to

action of low doses of X-radiation was given.



For the first time the new determination of relative biological efficiency

and quality coefficient of ionizing radiation in area of low doses are

proposed. 



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