RE: Another low-dose vs. high-dose biological response

["Jacobus, John (OD/ORS)" <jacobusj@ors.od.nih.gov>]

Jim,

I am curious as to why you think this is a significant study, if you do.  I

assume that you know biological mediators like cAMP follow all sorts of

stesses, environmental and biochemical.  The fact that the values should

change is not be a big surprise, at least not to me.  It would interesting

to compare these results with other tests of the cAMP/cGMP ratios in

response to other stresses.  I bet the ratio shifts are non-linear, also.

(I noted that the exposures were only made at 2 points, 0.5 and 5 Gy, so it

could be linear, but a doubt it is.  As I have said before, the fact that

the response is non-linear is also not surprising, as many molecular

responses are not non-linear.   

-- John



-----Original Message-----

From: Muckerheide [mailto:muckerheide@mediaone.net]

Sent: Thursday, November 01, 2001 6:48 PM

To: Jacobus, John (OD/ORS); rad-sci-l@ans.ep.wisc.edu;

radsafe@list.vanderbilt.edu

Subject: Re: Another low-dose vs. high-dose biological response





John,



Yes, and Don't know!? :-)

. . .

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