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Risks of low level radiation - New Scientist Article
Hi all,
Have fun with the "bystander effect".
Norm
> Source:
> <A HREF="http://www.newscientist.com/news/news.jsp?id=ns99991640">
> http://www.newscientist.com/news/news.jsp?id=ns99991640</A>
> ==========================================================
> Risks of low-level radiation higher than thought
>
> 04 December 01
> Hazel Muir
>
> Sources of low levels of radiation - such as radioactive radon gas
> seeping
> into houses - might cause more genetic damage and cancer than anyone
> realised, say a team of US researchers.
>
> "The effects of radiation are very complex," concludes Hongning Zhou
> of
> Columbia University in New York, a member of the team. "We should
> reconsider
> the risks of low levels."
>
> Current estimates of the risks of radiation come mainly from studies
> of
> cancer rates in survivors of the 1945 atomic bomb blasts in Hiroshima
> and
> Nagasaki, where the levels of radiation were very high. Scientists
> work out
> the risks of less intense radiation assuming that the cell damage
> falls off
> in direct proportion to the radiation dose.
>
> But that might not be true. Over the past few years, experiments have
> shown
> that the effects of radiation in cells are unexpectedly complicated
> due to a
> so-called "bystander effect", in which a radiated cell can alter the
> protein
> production of neighbouring cells.
>
> Now a team led by Tom Hei of Columbia University has measured the
> destructive
> effect of alpha particles on the genetic machinery of neighbouring
> cells.
>
>
> Mystery damage
>
>
> The team prepared layers of thousands of cells that are sensitive to
> mutations and targeted some of their nuclei with alpha particles. When
> they
> zapped 10 per cent of the cells with alpha particles, the number of
> cells
> with damaged DNA was similar to the number of casualties when they
> zapped all
> the cells.
>
> Why the neighbours suffer damage is a mystery. But it seems to be
> linked to a
> type of chemical communication in which the targeted cell exchanges
> small
> molecules with its nearest neighbours. When Zhou's team severed these
> chemical chat lines and repeated the alpha-particle assault, only the
> target
> cells were damaged.
>
> Until there are detailed studies of low-level radiation on animal and
> human
> tissues, no one will know if this is cause for alarm. "The effects on
> animals
> and people are likely to be even more complicated," says Richard
> Setlow, a
> biophysicist Brookhaven National Laboratory in Upton, New York. "But
> this is
> a clue what to look for."
>
> The result could fuel concerns over radon building up in confined
> spaces,
> such as the insulated basements of homes, as the gas leaks out of soil
> and
> rocks. The health risks of radon are controversial, but some
> scientists think
> it is responsible for thousands of deaths from lung cancer each year.
>
> However, Setlow says that the risks of radon cannot be much higher
> than
> currently predicted. If they were, we would see far more cancer cases
> from
> regions where radon gas is a problem.
>
> Journal reference: Proceedings of the National Academy of Sciences
> (vol 98, p
> 14,410)
>
> ==========================================================
>
>
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