Cases and Controls - Tom Mohaupt

["John Williams" <JohnWi@law.com>]

Tom,



There was no residual confounding noted in the Iowa Study. They 

checked for it.



Multivariate analysis is a very powerful tool for adjusting for 

smoking.  It does not require matched 1:1 case to control.  In fact, 

such matching gets you away from your population based design of the 

study. 



The alpha particle exposure from polonium 210 is adjusted for as part 

of the smoking adjustment (pack-year rate).  Tom,  recall that the 

overall effective dose from radon is reduced when the radon progeny 

attach to particulates from the tobacco smoke. 



As far as specifics of their adjustment, I would ask the Iowa authors 

for those details on their analyses.  They have kindly responded to 

all the questions I posed to them. In fact, if you check the archives 

Dr. Field himself spent many days discussing the study and responding 

to questions on this listserv.  I have seen no other author of any 

case-control study do the same.



As far as non smoking studies, Field refers to a positive German 

study in his debate and Becker.   See Kreuzer article in Br. j. of 

Med.  I have not had a chance to read it yet, have you?



http://www.ntp.org.uk/951-TUD.pdf





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