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Fw: Fw: Q1498 Submitted to ATE -- Second try for clarification
Mike,
Here is the original question and the response he sent when I asked for
clarification. Thanks, again.
-- John
> ----------
> From: Michael Stabin[SMTP:MICHAEL.G.STABIN@VANDERBILT.EDU]
> Sent: Thursday, January 10, 2002 9:42:27 AM
> To: Jacobus, John (OD/ORS)
> Subject: Re: Fw: Q1498 Submitted to ATE -- Second try for clarification
> Auto forwarded by a Rule
>
Dear John -
Sure, right up my alley, too, I do a lot of these studies. I worry a bit
(see below) about suggesting that this person get a consultant, because I
could possibly be a candidate, and I don't think Gen wants to use the AtE
page for people to promote their own business interests. I really think that
advice is appropriate, but if you or Gen have any reservations about that,
feel free to strike that phrase.
I think what you are asking is how we can determine human radiation dose
estimates for new pharmaceuticals based on biokinetic data gathered in
animal studies. If so, the basic procedure is to choose an animal species (a
number of considerations may come in here, including suitability of the
species in studying the drug of interest, cost, care issues, and others),
then administer the activity, monitor the results, extrapolate the results
to humans, perform a kinetic analysis, and finally calculate human radiation
dose estimates using standard models. Within each of these items, there are
a number of technical issues that must be considered and evaluated. It would
not be possible in the space here to give a complete overview of all of
these potential factors and how to resolve them. If you are needing to
actually perform such a study and are unfamiliar with these issues, you
might want to hire a consultant to ensure that all of the technical issues
are handled well and that all details are covered. If your interest is only
academic, I could send you a short technical paper that gives a few more
details than the sentence above, or perhaps the above is sufficient.
Michael G. Stabin, PhD, CHP
Assistant Professor of Radiology and Radiological Sciences
Department of Radiology and Radiological Sciences
Vanderbilt University
1161 21st Avenue South
Nashville, TN 37232-2675
Phone (615) 322-3190
Fax (615) 322-3764
e-mail michael.g.stabin@vanderbilt.edu
----- Original Message -----
From: Jacobus, John (OD/ORS) <jacobusj@ors.od.nih.gov>
To: <michael.g.stabin@vanderbilt.edu>
Cc: Genevieve S. Roessler <gnrsslr@frontiernet.net>
Sent: Thursday, January 10, 2002 7:41 AM
Subject: Fw: Fw: Q1498 Submitted to ATE -- Second try for clarification
> Mike,
> can you take this in trade for the one you sent?
>
> Obviously, communication is a problem, but I think he is asking for how is
> dose measured following the injection of a radionuclide. Do what you can
> send it back since it is my topic area.
>
> Also, do you have an e-mail address for ephraim who submitted 1520 that
you
> sent to me?
>
>
> -- John
> ----- Original Message -----
> From: "gshunmook" <gshunmook@forindia.com>
> To: "jenday1" <jenday1@email.msn.com>
> Sent: Tuesday, January 08, 2002 4:48 AM
> Subject: Re: Fw: Q1498 Submitted to ATE -- Second try for clarification
>
> dear sir,
>
> very sorry for late reply. exactely i need the radiation dose adminisitred
> in hunman body and how generally taht is measured ?
>
> On Saturday, December 29, 2001 at 12:01:44 PM, jenday1 wrote:
>
> > Dr. Sshunmugam,
> > Please respond if you have gotten this message.
> > -- John
> > Topic Editor for "Ask the Expert"
> >
> >
> > ----- Original Message -----
> > From: "jenday1" <jenday1@email.msn.com>
> > To: <gshunmook@forindia.com>
> > Sent: Saturday, December 15, 2001 11:23 AM
> > Subject: Fw: Q1498 Submitted to ATE
> >
> >
> > Dr. Shnmugam,
> > You submitted the following question to the "Ask the Expert" page of the
> > Health Physics Society Web site. To provide an adequate answer, I need
> some
> > additional information. By dose rate, do you mean the radiation dose to
> the
> > animal, or to the human investigators? Or do you mean the quantity of
> > radioactive material that you intend to give to the animal?
> >
> > -- John
> >
> > John Jacobus, MS
> > Certified Health Physicist
> > 3050 Traymore Lane
> > Bowie, MD 20715-2024
> > jenday1@email.msn.com (H)
> >
> >
> > ----- Original Message -----
> > From: <gshunmook@forindia.com>
> > To: <jacobusj@ors.od.nih.gov>; <jenday1@email.msn.com>
> > Sent: Friday, December 14, 2001 11:17 PM
> > Subject: Q1498 Submitted to ATE
> >
> >
> > John,
> >
> > On December 14, 2001, shunmugam submitted the following question through
> the
> > HPS Web site "Ask the Expert" page:
> >
> > NUMBER: Q1498
> > CATEGORY: Medical/Dental
> > QUESTION: "how can we find out the new radiopharmacuetical dose rate in
> > animal study?".
> >
> >
> >
> gshunmook
> e-mail: gshunmook@forindia.com
>