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Re: Lung cancer mortality from radon versus mortality from other<plus> RadonHealth Risks
Tom,
I was actually talking about a case-control study that showed hormesis.
If you read Alavanja's letter to the editor in the American Journal of
Epidemiology, he explains the limitations of that study.
The North American Residential radon pooling will likely shed some light on
never smokers.
Don
>From: Tom Mohaupt <tom.mohaupt@wright.edu>
>To: Rad health <healthrad@hotmail.com>
>CC: radsafe@list.vanderbilt.edu
>Subject: Re: Lung cancer mortality from radon versus mortality from
>other<plus> Radon Health Risks
>Date: Tue, 22 Jan 2002 14:15:33 -0500
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>From tom.mohaupt@wright.edu Tue, 22 Jan 2002 11:16:36 -0800
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>Don,
>There are negative studies of "never" smokers. Perhaps it's difficult to
>find studies of this group because lung cancer in it is relatively low.
>Most studies that are called "never smokers" actually comprise never and
>former smokers. Most suggest that chemical carcinogens and ETS exceed radon
>in causing lung cancer. Here are brief synopses of the MO, German, and
>Swedish studies.
>
>The first MO study of nonsmoking women was negative. The second study added
>smokers.
>Alavanja, M. et al., Residential Radon Exposure and Lung Cancer Among
>Nonsmoking Women, J Nat Cancer Inst (86)24, 1994, 1829-1837
>
>The German study was interesting. The study was negative for West Germany,
>but postive for the Eastern counterpart. Only five cases and 42 controls
>in the highest group (>140 Bq/m^3). All five cases were from East Germany.
>A strong association between chemical carcinogens and moderate associations
>for secondhand smoke and tuberculosis were evident. Eighty-six percent of
>the cases had radon levels less than 140 Bq/m^3.
>Kreuzer, M. et al., Lung Cancer in Lifetime nonsmoking men- Results of a
>Case-Control Study in Germany, Br J Cancer (2001) 84(1) 134-140
>
>The Swedish study was positive. They defined a never smoker as "a subject
>who had not smoked daily for 1 year or longer".
>RR for 101-200 Bq/m^3: 1.094 (compared to <25 Bq/m^3)
> 201-400 Bq/m^3: 1.086
> >400: 1.13
>Of interest, the RR (>140 Bq/m^3) excluding secondhand smoke was 1.13.
>Including secondhand smoke the RR was 2.1. This is consistent with an
>earlier Swedish study that showed a RR of 3.3 for secondhand smoke.
>Lagarde, F. et al., Residual Radon and Lung Cancer among Never-Smokers in
>Sweden, Epidemiology, (12)4, 2001
>
>
>
>Rad health wrote:
> >
> > MICHAEL,
> >
> >
> >
> > I noticed you didn't cite any of the
> > >studies that found negative associations
> >
> > Michael, Which case controls were negative? The only one I know about
>is
> > the China cave study that had a lot of problems with indoor cooking and
> > failure to account for gamma radiation in their eperms.
> >
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>--
>Thomas Mohaupt, M.S., CHP
>University Radiation Safety Officer
>
>104 Health Sciences Bldg
>Wright State University
>Dayton, Ohio 45435
>tom.mohaupt@wright.edu
>(937) 775-2169
>(937) 775-3761 (fax)
>
>"An investment in knowledge gains the best interest." Ben Franklin
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